Table 2 Patient demographics and baseline characteristics by TD cohort
Patient characteristics | TD N = 381 | No TD N = 150,899 | P value |
|---|---|---|---|
Age (years) | 51.4 ± 13.2 | 43.3 ± 13.6 | < 0.001 |
Index Diagnosis, %(n) | |||
 Bipolar disorder | 24.2% (92) | 35.2% (53,169) |  |
 Depressive disorder | 21.8% (83) | 33.3% (50,213) | < 0.001 |
 Schizophrenia | 54.1% (206) | 31.5% (47,517) |  |
Generation of index AP | |||
 First generation | 16.8% (64) | 10.5% (15,850) |  |
 Multiple | 3.4% (13) | 2.3% (3,424) | < 0.001 |
 Second generation | 79.8% (304) | 87.2% (131,625) |  |
 Chlorpromazine equivalent daily dose (100 mg/day) | 2.78 ± 2.29 | 2.29 ± 2.11 | < 0.001 |
CCI | 0.64 ± 1.18 | 0.53 ± 1.16 | 0.05 |
 Diabetes | 23.9% (91) | 14.4% (21,674) | < 0.001 |
 Bipolar and related disorders | 26.0% (99) | 31.9% (48,075) | < 0.05 |
 Depressive disorders | 32.6% (124) | 42.6% (64,301) | < 0.001 |
 Bradykinesia | 9.7% (37) | 3.3% (4,917) | < 0.001 |
 Dystonia | 0.8% (3) | 0.1% (131) | < 0.001 |
 Myoclonus | 1.1% (4) | 0.1% (91) | < 0.001 |
 Parkinsonism | 0.8% (3) | 0.1% (119) | < 0.001 |
 History of EPS | 12.3% (47) | 4.2% (6,388) | < 0.001 |
 Number of EPS | 0.14 ± 0.41 | 0.05 ± 0.23 | < 0.001 |