Fig. 3From: Co-morbidity of progressive supranuclear palsy and amyotrophic lateral sclerosis: a clinical-pathological case reportMicroscopic findings. The cervical spinal cord showed severe neuronal loss of anterior horn cells (a) and Bunina bodies (b). Neuronophagia was observed in the precentral gyrus (c). Phosphorylated TDP-43 neuronal cytoplasmic inclusions were present in the precental gyrus (d). Globose-shaped neurofibrillary tangle (NFT) was detected in the substantia nigra by H-E staining (e) and immunostaining for phosphorylated tau (f) and 4-repeat tau (g). Tufted astrocytes were present in the putamen (h). Scale bars: 500 μm (a), 20 μm (b-h)Back to article page