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Table 2 Efficacy Measures at 6 months

From: Remote ischemic conditioning improves cognition in patients with subcortical ischemic vascular dementia

Efficacy Measure RIC Group (n = 18) p Control Group (n = 19) p
Before After Before After
HVLT-R
 HVLT1 12.56 ± 4.15 16.89 ± 4.23 0.002 13.05 ± 5.33 16.05 ± 5.65 0.017
 HVLT2 2.72 ± 2.61 4.72 ± 3.12 0.036 2.53 ± 2.80 4.53 ± 3.32 0.013
 HVLT3 6.22 ± 2.21 8.83 ± 1.89 0.000 6.05 ± 2.44 7.42 ± 3.04 0.023
 COWAT 5.11 ± 3.34 6.39 ± 3.33 0.030 5.00 ± 3.32 5.53 ± 3.89 0.455
 TMT-A 125.83 ± 69.54 102.50 ± 57.33 0.007 131.88 ± 86.06 128.47 ± 112.45 0.848
 TMT-B 262.83 ± 122.24 209.17 ± 108.98 0.015 244.61 ± 116.05 197.28 ± 133.79 0.007
 SDMT 19.67 ± 9.32 21.17 ± 9.93 0.426 23.61 ± 15.34 21.72 ± 14.99 0.249
 JLO 17.94 ± 7.60 23.22 ± 4.66 0.006 17.50 ± 5.76 18.44 ± 7.53 0.398
 ADL 25.33 ± 2.61 24.72 ± 1.60 0.102 25.11 ± 2.18 24.84 ± 1.43 0.426
 NPI 2.06 ± 1.11 1.72 ± 0.83 0.083 1.74 ± 1.05 1.53 ± 0.77 0.215
 hs-CRP 2.38 ± 2.87 1.30 ± 1.35 0.221 1.63 ± 1.71 1.67 ± 1.80 0.951
 IL-6 16.26 ± 7.05 15.85 ± 6.70 0.072 16.25 ± 4.99 15.81 ± 4.27 0.125
 TNF-α 5.64 ± 1.12 5.57 ± 1.02 0.167 5.54 ± 0.83 5.46 ± 0.72 0.155
 WMLV (cm3) 84.00 ± 53.82 69.87 ± 45.76 0.060 71.26 ± 28.03 68.35 ± 23.20 0.569
WBWM
 FA 0.30 ± 0.02 0.29 ± 0.02 0.348 0.31 ± 0.02 0.30 ± 0.04 0.446
 MD(×10−4) 9.5 ± 0.79 9.6 ± 0.84 0.128 8.9 ± 0.33 9.1 ± 0.62 0.288
NAWM
 FA 0.30 ± 0.02 0.30 ± 0.02 0.293 0.31 ± 0.02 0.30 ± 0.04 0.427
 MD(×10−4) 9.0 ± 0.73 9.4 ± 0.60 0.136 8.6 ± 0.37 8.9 ± 0.60 0.097
  1. Abbreviations: ADL Activities of daily living, COWAT Controlled Oral Word Association Test, the outcome was the sum of correct words in the both parts, FA fractional anisotropy, hs-CRP high-sensitive C-reactive protein, HVLT1 immediate memory of Hopkins Verbal Learning Test-Revised (HVLT-R), HVLT2 delayed memory of HVLT-R, HVLT3 recognition test of HVLT-R, IL-6 interleukin 6, JLO Judgment of Line Orientation, MD mean diffusivity, NAWM normal-appearing white matter, NPI Neuropsychiatric Inventory, SDMT Symbol Digit Modalities Test, TMT-A Trail Making Test A, TMT-B Trail Making Test B, TNF-α tumor necrosis factor-alpha, WBWM whole-brain white matter, WMLV white matter lesion volume
  2. Notes: Paired t-test was used to evaluate the effect of the treatments in the group