Skip to main content

Table 1 Titers and lab values

From: Demyelinating syndrome in systemic sclerosis and neuromyelitis optica

Test name Titers Reference ranges
  Neuromyelitis Optica... 7.7 A Negative 0.0–3.0;Indeterminate 3.1–5.0;Positive > 5.1
ANA Positive  
ANTI-DNA < 1.0 Negative: <=4.9 IU/mL;Indeterminate: 5–9.9 IU/mL;Positive: > = 10 IU/mL
Smooth Muscles SM AB < 0.2 Negative: < 1.0;Positive: > = 1.0
Neutrophil Cytoplasmic Ab C-ANCA < 0.2, P-ANCA < 0.2 Negative: < 1.0;Positive: > = 1.0
Scleroderma 70 Ab SCLERODERM... 4.5 H Negative: < 1.0;Positive: > = 1.0
JO-1 ANTIB... <  0.2 Negative: < 1.0;Positive: > = 1.0
CENTROMERE AB... <  0.2 Negative: < 1.0;Positive: > = 1.0
Sjorgen ANTI-SSA... <  0.2, ANTI-SSB... <  0.2 Negative: < 1.0;Positive: > = 1.0
RNP AB < 0.2 Negative: < 1.0;Positive: > = 1.0
CHROMATIN ... <  0.2 Negative: < 1.0;Positive: > = 1.0
RA Negative  
HBsAg Scre... NEGATIVE  
HEP B SURF... NEGATIVE  
RNA Polymerase III IgG Abs 40 Units/mL Negative: < 20;Weak Positive: 20–39;Moderate Positive: > 40–80;Strong Positive: > 80a
C3 131  
C4 40  
HIV By By RT-PCR HIV RNA... Target Not Detected  
Toxoplasma Igg TOXOPLASMA... 27.0 H,  
TOXOPLASMA... 0.24 <  0.9 Negative;0.9–0.99 Equivocal;>  1.00 Positive
MYELIN BASIC PROTEIN... 6.3 A  
EBV EARLY ... <  0.20, EBV NUCLEA... >  8.00 H,  
EBV VCA IG... >  8.0 H, EBV VCA IG... <  0.2 < OR = 0.8 AI: NEGATIVE;0.9–1.0 AI: EQUIVOCAL;> OR = 1.1 AI: POSITIVE
VARICELLA IgG … .3.3 < OR = 0.8 AI: NEGATIVE;0.9–1.0 AI: EQUIVOCAL;> OR = 1.1 AI: POSITIVE
HTLV I/II ... TNP  
Epst Barr Virus DNA Epst Barr ... Negative  
Varicella Zoster Ab Pcr (Csf) VARICELLA ... Negative  
Crypto.Ag,Csf CRYPTO.AG,... Negative  
Herpes Virus Dna By Pcr HSV1 DNA P... Negative, HSV2 DNA P... Negative  
Lyme Disease Ab (Csf) B.burgd Ig... < 0.08, B.burgd Ig... < 0.06 Negative: < or = 0.09;Positive: >  0.09B.
Enterovirus... Negative  
CSF VDRL Nonreactive  
IGG 1500  
Coccidioides Abs, CSF (CF) < 1:2 < 1:2  
Coccidioides Ab, IgG 0.1 IV < =0.9  
Toxo IgG C... < 3.0  
Oligoclonal OLIGOCLONAL ab negative  
GLUCOSE, C... 99 H; PROT.,CSF 55.6 H  
Immunofix/Pep Csf Profile PROTEIN (C... 36.9, PREALBUMIN 2.9,  
ALBUMIN 54.5 A, ALPHA-1-GL... 4.1, ALPHA-2-GL... 6.4,  
BETA GLOBU... 17.8, GAMMA GLOB... 14.4 A  
Lymph/Leuk Body Fluid plasma cells are not identified T cells with an increased CD4/CD8 ratio are detected. b
ANGIOTENSIN ENZYM < 15  
Renin Activity... 13.774 A  
D-DIMER 476 H  
CORTISOL 34.66  
TSH 0.910  
ESR 86 H  
CRP-HIGH S... 1.910 H  
  1. aRNA Polymerase III is strongly associated with diffuse cutaneous scleroderma and with an increases risk of acute renal crisis. A positive result supports a possible diagnosis of systemic sclerosis while a negative result does not rule out the possibility of systemic sclerosis, as the sensitivity for detection of RNA Polymerase III is between 11 and 23%
  2. bFlow cytometric analysis identifies a population of lymphocytes (91.1% of all analyzed events) that consists of a mixture of minute B-cell population (2.7% of cells in this gate), T cells with an increased CD4/CD8 ratio of 7.8 and mild down-regulation of CD7 expression (91.6% of cells in this gate), and NK-cells (2.0% of cells in this gate). An increased CD4/CD8 ratio is a non-specific finding that may be seen in reactive / inflammatory processes and autoimmune disease; less likely, it may represent an atypical population. The B-cells show minimal lambda excess, the significance of which is uncertain