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Table 2 Clinical background of patients with positive and negative CSF for JCV DNA

From: Improving detection of JC virus by ultrafiltration of cerebrospinal fluid before polymerase chain reaction for the diagnosis of progressive multifocal leukoencephalopathy

Patient CSF JCV Age (y) Sex Underlying disease Immunosuppressive factor
1 Positive 88 F Chronic lymphocytic leukemia Unknowna
2 Positive 58 F Systemic lupus erythematosus
Lupus nephritis
Sjögren’s syndrome
Prednisolone
Methotrexate
3 Positive 59 F Nephrotic syndrome Prednisolone
4 Positive 36 F Systemic lupus erythematosus Prednisolone
Cyclophosphamide
5 Positive 38 F Systemic lupus erythematosus
Lupus nephritis
Prednisolone
Mycophenolate mofetil
6 Positive 42 M HIV infection AIDS
7 Positive 63 F Multiple sclerosis Fingolimod
8 Positiveb 41 M HIV infection AIDS
9 Negative 70 F Sarcoidosis Prednisolone
10 Negative 34 M Diffuse large B-cell lymphoma Cytarabine
Methotrexate
Rituximab
11 Negative 65 M Liver disease (transplantation) Tacrolimus
Mycophenolate mofetil
12 Negative 67 F Drug-induced nephropathy Cyclosporine
13 Negative 52 M No disease Unknown
14 Negative 81 F Burkitt’s lymphoma Chemotherapy (R-EPOCH)
Methotrexate
15 Negative 72 M No disease Unknown
16 Negative 48 F Multiple sclerosis Glatiramer acetate
17 Negative 56 M Adult T-cell leukemia/lymphoma Thymoglobulin
Chemotherapy (mLSG15)
18 Negative 53 M No disease Unknown
19 Negative 50 M HIV infection AIDS
20 Negative 53 F Follicular lymphoma Chemotherapy (R-CHOP)
Methotrexate
  1. Abbreviations: AIDS Acquired immunodeficiency syndrome, CSF Cerebrospinal fluid, HIV Human immunodeficiency virus, JCV JC virus, mLSG15 modified Lymphoma Study Group 15, R-EPOCH Rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, R-CHOP Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone
  2. aPatient received neither radiation therapy nor chemotherapy
  3. bJCV DNA was detected in the ultrafiltrated CSF specimen