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Table 3 Distribution of brain lesions and neurologic symptoms in patients with JCV-positive and JCV-negative CSF samples

From: Improving detection of JC virus by ultrafiltration of cerebrospinal fluid before polymerase chain reaction for the diagnosis of progressive multifocal leukoencephalopathy

   MRI (T2/FLAIR) lesion (%)a  
Patient JCV DNA Cerebral white matter Cerebellar white matter Brain stem Pattern Symmetry Neurologic symptom
1 Positive + Bilateral Asymmetric Quadriplegia, Consciousness disorder, Aphasia, Involuntary movement, Increased deep tendon reflex
2 Positive + Unilateral Asymmetric Cerebellar symptom
3 Positive + + Bilateral Asymmetric Hemiplegia, Mental manifestation, Dysarthria, Dysphagia, Increased deep tendon reflex
4 Positive + Unilateral Asymmetric Cerebellar symptom
5 Positive + + Bilateral Asymmetric Dysarthria, Sensory disturbance, Cerebellar symptom
6 Positive + + + Bilateral Asymmetric Consciousness disorder, Mental manifestation, Aphasia, Dysarthria, Dysphagia, Sensory disturbance, Involuntary movement
7 Positive + Bilateral Asymmetric Consciousness disorder, Aphasia
8 Positivea + + + Bilateral Asymmetric Hemiplegia, Consciousness disorder, Increased deep tendon reflex, Cerebellar symptom
9 Negative + Unilateral Asymmetric Hemiplegia, Consciousness disorder, Aphasia
10 Negative + Bilateral Asymmetric Increased deep tendon reflex
11 Negative + Unilateral Asymmetric Sensory disturbance
12 Negative + Bilateral Symmetric Sensory disturbance
13 Negative + Bilateral Symmetric Consciousness disorder, Mental manifestation
14 Negative + Bilateral Symmetric Consciousness disorder
15 Negative + Bilateral Asymmetric Consciousness disorder, Dysarthria
16 Negative + + Bilateral Asymmetric Consciousness disorder, Sensory disturbance
17 Negative + + Bilateral Symmetric Quadriplegia, Consciousness disorder
18 Negative + + + Bilateral Symmetric Dysarthria, Cerebellar symptom
19 Negative + + + Bilateral Symmetric Consciousness disorder, Dysarthria, Sensory disturbance, Increased deep tendon reflex, Cerebellar symptom
20 Negative + Bilateral Symmetric Consciousness disorder, visual disturbance, Dysarthria, Dysphagia, Sensory disturbance
  1. Abbreviations: CSF Cerebrospinal fluid, FLAIR Fluid-attenuated inversion recovery, JCV JC virus, MRI Magnetic resonance imaging
  2. aPlus indicates that MRI lesions were identified, while minus indicates that no lesions were found
  3. bJCV DNA was detected in ultrafiltrated CSF specimen