Fig. 2
From: Palbociclib in combination with simvastatin induce severe rhabdomyolysis: a case report
A: Skeletal muscle histopathology: A, Hematoxylin/Eosin (HE); B, Gomoris modified trichrom; C, fast myosin heavy chain (MHCf); D, slow myosin heavy chain (MHCs); E, CD8; F, macrophages (Mac); G, MHC Class 1 /HLA-ABC; H, Vimentin (Vim); I, succinyldehydrogenase SDH); J, Cytochrome C oxidase (COX). The black bar represents 50 μm. B: Magnetic resonance imaging of lower extremities. A, axial (Ax) T1-weighted Fast spin echo (FSE) sequence. B, Ax T1-wheigted FSE and fat saturated (Fs) with gadolinium contrast (Gd) sequence. C, coronal (Cor) T1-weighted Short-TI Inversion Recovery (STIR) sequence. In picture B the hyper intense signals in muscles Vastus Intermedius (I), Adductor Magnus (A), Vastus Lateralis (L) and Gracilis (G) indicate muscle edema. In picture C the arrows point to missing STIR signal In L that can be a sign of muscle necrosis