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Table 1 Clinical features of the past reported cases that developed PML after lung transplantation

From: Probable progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome with immunosuppressant dose reduction following lung transplantation: a case report and literature review

Case (year) Age
/Sex
Immuno-
Suppressant regimen
Time to PML onset from transplantation (Mo) Clinical
Symptoms
Method of diagnosis
(specimen)
Reduced immunosupressant as therapy Treatment for PML From PML onset to diagnosis (Mo) Outcome (cause of death/ period from onset to death; Mo)
Ouwens JP
(2000) [3]
43/M AZA
CsA
CS
15 Visual loss, seizure, visual hallucination, ataxia, rt.paresis, dysarthria, memory impairment PCR (CSF) RD
Change
(AZA→MMF→CsA)
- 13 Died (PML / 15)
Waggoner J
(2009) [4]
38/F AZA,Tac, CS,Alemtuzumab, 43 Gait instability (ataxia)
Visual changes, confusion
PCR (CSF) RD cidofovir
mirtazapine
1.5 ~ 2 Died (respiratory failure / 5)
Mateen FJ
(2011) [2]
39/F - 42 Ataxia PCR (CSF) RD mirtazapine,
mefloquine
3 Died (ND / 9.1)
Mateen FJ
(2011) [2]
62/F - 27 Memory impairment, Ataxia, lt. hemiparesis PCR (CSF) RD - < 1 Died (ND /15.6)
Lobo LJ
(2013) [5]
61/M Rituximab
CsA
MMF
CS
13 Headache, Malaise
Memory impairment
PCR (CSF) RD - ND Neurologic symptoms exacerbation, move to hospice
Moua T
(2013) [6]
61/M Tac
CS
5 Rt. Hemiparesis & sensory disturbance, cognitive decline, aphasia ISH (brain biopsy) RD cytarabine 3 Died (ARE?/ 7)
Panchabhai TS (2016) [7] 60/F Tac
CS
16 Lt. arm paresis, Memory impairment, visual deficits, emotional lability, PCR (BALF & CSF) Change (Tac→rapamycin), Discontinued - 2 Died (respiratory failure: ARE / 3)
Present case 60/F Tac
MMF
CS
61 Apathy PCR (CSF) RD mefloquine 2 Died (respiratory failure / 5)
  1. AZA Azathioprine, CsA Cyclosporine, CS Corticosteroid, Tac Tacrolimus, MMF Mycophenolate mofetil, CSF Cerebrospinal fluid, PCR Polymerase chain reaction, ISH In-situ hybridization, BALF Bronchoalveolar lavage fluid, RD Reduced doses, ND Not described, ARE Acute rejection episode,