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Table 2 Genotype and allele frequency distributions of SNPs in IS and controls

From: Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population

 Control group (%)IS groupLAA groupCES groupSVO group
n(%)P valueOR(95%CI)P valueOR(95%CI)P valueOR(95% CI)P valueOR(95% CI)
rs5788
 Genotype
  CC810 (89.7)974 (90.4)ReferenceReferenceReferenceReference
  CA89 (9.9)102 (9.5)0.3842.634 (0.297–23.332)0.6570.894 (0.545–1.466)0.4651.254(0.684–2.298)0.4330.824 (0.507–1.338)
  AA4 (0.4)2 (0.2)0.4262.450 (0.270–22.255)0.8180.742 (0.058–9.471)NA0.5390.380 (0.017–8.288)
  CA + AA vs CC  0.6000.907 (0.629–1.307)0.6340.888 (0.546–1.446)0.5251.216 (0.665–2.224)0.3830.808 (0.500–1.305)
  AA vs CC + CA  0.3880.382 (0.043–3.387)0.8250.750 (0.059–9.572)NA0.5460.386 (0.018–8.454)
 Allele
  C1709 (94.6)2050 (95.1)ReferenceReferenceReferenceReference
  A97 (5.4)106 (4.9)0.4980.884 (0.618–1.263)0.5100.851 (0.528–1.374)0.5861.173 (0.660–2.085)0.4130.824 (0.519–1.309)
rs1330344
 Genotype
  GG126 (14.0)177 (16.4)ReferenceReferenceReferenceReference
  GA456 (50.5)510 (47.3)0.3500.827 (0.555–1.232)0.4260.815 (0.402–1.350)0.5030.809 (0.436–1.503)0.2070.739 (0.463–1.182)
  AA321 (35.5)391 (36.3)0.0440.657 (0.437–0.988)0.1080.652 (0.387–1.099)0.0430.506 (0.262–0.978)0.0480.616 (0.382–0.995)
  GA + AA vs GG  0.1330.794 (0.587–1.073)0.2390.781 (0.517–1.179)0.1780.699 (0.415–1.177)0.0500.690 (0.475–1.000)
  AA vs GG + GA  0.5880.939 (0.748–1.179)0.6230.927 (0.685–1.254)0.1320.723 (0.474–1.102)0.6980.944 (0.708–1.260)
 Allele
  G708 (39.2)864 (40.1)ReferenceReferenceReferenceReference
  A1098 (60.8)1292 (59.9)0.0290.812 (0.675–0.978)0.0340.778 (0.618–0.981)0.0230.702 (0.518–0.951)0.0970.829(0.665–1.035)
rs3842788
 Genotype
  GG795 (88.0)890 (82.6)ReferenceReferenceReferenceReference
  GA97 (10.7)120 (11.1)0.3370.821 (0.549–1.228)0.1220.652 (0.379–1.122)0.8610.944 (0.495–1.801)0.5910.876 (0.540–1.420)
  AA11 (1.3)68 (6.3)0.1655.127 (0.511–5.428)0.1287.858 (0.552–111.969)0.0829.758 (0.748–12.273)0.3264.586 (0.219–5.902)
  GA + AA vs GG  0.4870.868 (0.583–1.293)0.2060.711 (0.419–1.207)0.8821.048 (0.562–1.955)0.6920.908 (0.563–1.465)
  AA vs GG + GA  0.0165.203 (1.519–5.159)0.1218.167 (0.573–16.414)0.0419.821 (2.754–12.832)0.0254.603 (1.220–5.201)
 Allele
  G1687 (93.4)1900 (88.1)ReferenceReferenceReferenceReference
  A119 (6.6)256 (11.9)0.6990.928 (0.635–1.355)0.3540.789 (0.479–1.302)0.6201.157 (0.650–2.057)0.8170.947 (0.600–1.496)
rs20417
 Genotype
  GG812 (89.9)977 (90.6)ReferenceReferenceReferenceReference
  GC87 (9.6)97 (9.0)0.6801.080 (0.748–1.561)0.4241.223 (0.746–2.006)0.8121.084 (0.556–2.114)0.4231.211 (0.758–1.935)
  CC4 (0.4)4 (0.4)0.341421 (0.071–2.500)0.5280.443 (0.035–5.560)0.4790.335 (0.016–6.937)0.5280.499 (0.058–4.315)
  GC + CC vs GG  0.8201.043 (0.726–1.498)0.5131.177 (0.723–1.915)0.9531.020 (0.528–1.970)0.5131.166 (0.736–1.848)
  CC vs GG + GC  0.3780.418 (0.070–2.482)0.5190.436 (0.035–5.460)0.4770.334 (0.016–6.899)0.5180.492 (0.057–4.239)
 Allele
  G1711 (94.7)2051 (95.1)ReferenceReferenceReferenceReference
  C95 (5.3)105 (4.9)0.9520.987 (0.655–1.489)0.6301.137 (0.675–1.914)0.9630.984 (0.504–1.924)0.6461.124 (0.684–1.847)
rs689466
 Genotype
  GG189 (20.9)241 (22.4)ReferenceReferenceReferenceReference
  GA472 (52.3)519 (48.1)0.4080.888 (0.671–1.176)0.4350.861 (0.592–1.253)0.6761.116 (0.666–1.872)0.2300.805 0.565–1.147)
  AA242 (26.8)318 (29.5)0.5351.104 (0.807–1.511)0.2621.266 (0.838–1.910)0.8711.050 (0.581–1.897)0.8831.030 (0.692–1.533)
  GA + AA vs GG  0.7580.959 (0.735–1.251)0.9600.991 (0.697–1.409)0.7911.095 (0.667–1.797)0.4380.876 (0.627–1.224)
  AA vs GG + GA  0.1401.201 (0.941–1.531)0.0381.404 (1.019–1.934)0.8900.969 (0.617–1.520)0.2511.200 (0.879–1.638)
 Allele
  G850 (47.1)1001 (46.4)ReferenceReferenceReferenceReference
  A956 (52.9)1155 (53.6)0.9690.996 (0.829–1.198)0.5411.076 (0.851–1.360)0.7990.962 (0.712–1.300)0.6780.954 (0.764–1.192)
  1. Using multivariate analysis after adjusting for age, gender and traditional risk factors
  2. P < 0.05 in bold
  3. NA Not available
  4. Reference: means allele homozygote as a reference