Table 3 Genotype and allele frequency distributions of SNPs in hypertension/diabetes/smoking and their controls
| Â | Hypertension | Diabetes | Smoking | ||||||
|---|---|---|---|---|---|---|---|---|---|
control = 1098(%) | n = 883(%) | P value | control = 1561(%) | n = 420(%) | P value | control = 1368(%) | n = 613(%) | P value | |
rs5788 | |||||||||
 CC | 991(90.3) | 793(89.8) | – | 1399(89.6) | 385(91.7) | – | 1242(90.8) | 542(88.4) | – |
 CA | 103(9.4) | 88(10.0) | 0.915 | 156(10.0) | 35(8.3) | 0.259 | 123(9.0) | 68(11.1) | 0.050 |
 AA | 4(0.4) | 2(0.2) | 0.947 | 6(0.4) | 0 | NA | 3(0.2) | 3(0.5) | 0.269 |
 CA + AA vs CC | – | – | 0.338 | – | – | 0.195 | – | – | 0.034 |
 AA vs CC + CA | – |  | 0.930 | – | – | NA | – | – | 0.286 |
 C | 2085(94.9) | 1674(94.8) | – | 2954(94.6) | 805(95.8) | – | 2607(95.3) | 1152(94.0) | – |
 A | 111(5.1) | 92(5.2) | 0.502 | 168(5.4) | 35(4.2) | 0.084 | 129(4.7) | 74(6.0) | 0.081 |
rs1330344 | |||||||||
 GG | 168(15.3) | 135(15.3) | – | 229(14.7) | 74(17.6) | – | 218(15.9) | 85(13.9) | – |
 GA | 549(50.0) | 417(47.2) | 0.188 | 790(50.6) | 176(41.9) | 0.047 | 654(47.8) | 312(50.9) | 0.102 |
 AA | 381(34.7) | 331(37.5) | 0.121 | 542(34.7) | 170(40.5) | 0.887 | 496(36.3) | 216(35.2) | 0.133 |
 GA + AA vs GG | – | – | 0.128 | – | – | 0.270 | – | – | 0.092 |
 AA vs GG + GA | – | – | 0.388 | – | – | 0.025 | – | – | 0.662 |
 G | 885(40.3) | 687(38.9) | – | 1248(40.0) | 324(38.6) | – | 1090(39.8) | 482(39.3) | – |
 A | 1311(59.7) | 1079(61.1) | 0.284 | 1874(60.0) | 516(61.4) | 0.470 | 1646(60.2) | 744(60.7) | 0.649 |
rs3842788 | |||||||||
 GG | 978(89.1) | 779(88.2) | – | 1378(88.3) | 379(90.2) | – | 1198(87.6) | 559(91.2) | – |
 GA | 118(10.7) | 97(11.0) | 0.381 | 176(11.3) | 39(9.3) | 0.337 | 163(11.9) | 52(8.5) | 0.030 |
 AA | 2(0.2) | 7(0.8) | 0.286 | 7(0.4) | 2(0.5) | 0.474 | 7(0.5) | 2(0.3) | 0.506 |
GA + AA vs GG | – | – | 0.284 | – | – | 0.274 | – | – | 0.025 |
AA vs GG + GA | – | – | 0.294 | – | – | 0.490 | – | – | 0.535 |
 G | 2074(94.4) | 1655(93.7) | – | 2932(93.9) | 797(94.9) | – | 2559(93.50 | 1170(95.4) | – |
 A | 122(5.6) | 111(6.3) | 0.173 | 190(6.1) | 43(5.1) | 0.197 | 177(6.5) | 56(4.6) | 0.023 |
rs20417 | |||||||||
 GG | 988(90.0) | 801(90.7) | – | 1399(89.6) | 390(92.9) | – | 1236(90.4) | 553(90.2) | – |
 GC | 107(9.7) | 77(8.7) | 0.868 | 157(10.1) | 27(6.4) | 0.036 | 124(9.1) | 60(9.8) | 0.733 |
 CC | 3(0.3) | 5(0.6) | 0.249 | 5(0.3) | 3(0.7) | 0.306 | 8(0.6) | 0 | NA |
 GC + CC vs GG | – | – | 0.942 | – | – | 0.067 | – | – | 0.955 |
 CC vs GG + GC | – | – | 0.248 | – | – | 0.285 | – | – | NA |
 G | 2083(94.9) | 1679(95.1) | – | 2955(94.7) | 807(96.1) | – | 2596(94.9) | 1166(95.1) | – |
 C | 113(5.1) | 87(4.9) | 0.762 | 167(5.3) | 33(3.9) | 0.093 | 140(5.1) | 60(4.9) | 0.881 |
rs689466 | |||||||||
 GG | 241(21.9) | 189(21.4) | – | 324(20.8) | 106(25.2) | – | 297(21.7) | 133(21.7) | – |
 GA | 560(51.0) | 431(48.8) | 0.374 | 786(50.4) | 205(48.8) | 0.229 | 692(50.6) | 299(48.8) | 0.792 |
 AA | 297(27.0) | 263(29.8) | 0.063 | 451(28.9) | 109(26.0) | 0.036 | 379(27.7) | 181(29.5) | 0.745 |
 GA + AA vs GG | – | – | 0.164 | – | – | 0.085 | – | – | 0.750 |
 AA vs GG + GA | – | – | 0.094 | – | – | 0.087 | – | – | 0.835 |
 G | 1042(47.4) | 809(45.8) | – | 1434(45.9) | 417(49.6) | – | 1286(47.0) | 565(46.1) | – |
 A | 1154(52.6) | 957(54.2) | 0.063 | 1688(54.1) | 423(50.4) | 0.025 | 1450(53.0) | 661(53.9) | 0.317 |