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Table 3 Genotype and allele frequency distributions of SNPs in hypertension/diabetes/smoking and their controls

From: Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population

 HypertensionDiabetesSmoking
control = 1098(%)n = 883(%)P valuecontrol = 1561(%)n = 420(%)P valuecontrol = 1368(%)n = 613(%)P value
rs5788
 CC991(90.3)793(89.8)1399(89.6)385(91.7)1242(90.8)542(88.4)
 CA103(9.4)88(10.0)0.915156(10.0)35(8.3)0.259123(9.0)68(11.1)0.050
 AA4(0.4)2(0.2)0.9476(0.4)0NA3(0.2)3(0.5)0.269
 CA + AA vs CC0.3380.1950.034
 AA vs CC + CA 0.930NA0.286
 C2085(94.9)1674(94.8)2954(94.6)805(95.8)2607(95.3)1152(94.0)
 A111(5.1)92(5.2)0.502168(5.4)35(4.2)0.084129(4.7)74(6.0)0.081
rs1330344
 GG168(15.3)135(15.3)229(14.7)74(17.6)218(15.9)85(13.9)
 GA549(50.0)417(47.2)0.188790(50.6)176(41.9)0.047654(47.8)312(50.9)0.102
 AA381(34.7)331(37.5)0.121542(34.7)170(40.5)0.887496(36.3)216(35.2)0.133
 GA + AA vs GG0.1280.2700.092
 AA vs GG + GA0.3880.0250.662
 G885(40.3)687(38.9)1248(40.0)324(38.6)1090(39.8)482(39.3)
 A1311(59.7)1079(61.1)0.2841874(60.0)516(61.4)0.4701646(60.2)744(60.7)0.649
rs3842788
 GG978(89.1)779(88.2)1378(88.3)379(90.2)1198(87.6)559(91.2)
 GA118(10.7)97(11.0)0.381176(11.3)39(9.3)0.337163(11.9)52(8.5)0.030
 AA2(0.2)7(0.8)0.2867(0.4)2(0.5)0.4747(0.5)2(0.3)0.506
GA + AA vs GG0.2840.2740.025
AA vs GG + GA0.2940.4900.535
 G2074(94.4)1655(93.7)2932(93.9)797(94.9)2559(93.501170(95.4)
 A122(5.6)111(6.3)0.173190(6.1)43(5.1)0.197177(6.5)56(4.6)0.023
rs20417
 GG988(90.0)801(90.7)1399(89.6)390(92.9)1236(90.4)553(90.2)
 GC107(9.7)77(8.7)0.868157(10.1)27(6.4)0.036124(9.1)60(9.8)0.733
 CC3(0.3)5(0.6)0.2495(0.3)3(0.7)0.3068(0.6)0NA
 GC + CC vs GG0.9420.0670.955
 CC vs GG + GC0.2480.285NA
 G2083(94.9)1679(95.1)2955(94.7)807(96.1)2596(94.9)1166(95.1)
 C113(5.1)87(4.9)0.762167(5.3)33(3.9)0.093140(5.1)60(4.9)0.881
rs689466
 GG241(21.9)189(21.4)324(20.8)106(25.2)297(21.7)133(21.7)
 GA560(51.0)431(48.8)0.374786(50.4)205(48.8)0.229692(50.6)299(48.8)0.792
 AA297(27.0)263(29.8)0.063451(28.9)109(26.0)0.036379(27.7)181(29.5)0.745
 GA + AA vs GG0.1640.0850.750
 AA vs GG + GA0.0940.0870.835
 G1042(47.4)809(45.8)1434(45.9)417(49.6)1286(47.0)565(46.1)
 A1154(52.6)957(54.2)0.0631688(54.1)423(50.4)0.0251450(53.0)661(53.9)0.317
  1. Using multivariate analysis after adjusting for age, gender and traditional risk factors
  2. P < 0.05 in bold