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Fig. 2 | BMC Neurology

Fig. 2

From: PPAR-γ promotes p38 MAP kinase-mediated endothelial cell permeability through activating Sirt3

Fig. 2

Sirt3 promotes endothelial cell proliferation and inhibits cell apoptosis. a, Cell growth curves of endothelial cells were generated using CCK8 during post-reperfusion stages (24–72 h), as compared to control groups with no reperfusion treatment (0 h). b, Cell apoptosis analysis of cells at 24 h of reperfusion after I/R injury. Cells were either from normal HBMECs with SIRT3 inhibition (BLANK and 3-TYP), or from I/R injury HBMECs at 24 h of post-reperfusion with SIRT3 overexpression, together with or without U-46619 treatment (Control, Vector, Sirt3 and Sirt3 + U-46619). ***, p < 0.001 as compared to the normal HBMECs model (BLANK). ###, p < 0.001 as compared to the non-overexpression control group (Control) and!!! as compared to the Sirt3 overexpression group (Sirt3)

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