Low free triiodothyronineis predicts worsen neurological outcome of patients with acute ischemic stroke: a retrospective study with bioinformatics analysis

Table 6 Multiple logistic regression analysis of poor functional outcome predictors

Variables	OR	95% CI	p-value
Univariate analysis
Sex(n)	0.440	0.25–3.97	0.468
Age (years)	1.251	1.01–1.71	0.031
Hypertension (n)	0.922	0.58–1.72	0.609
Diabetes (n)	1.780	1.14–2.85	0.064
Hyperlipidemia (n)	1.240	0.51–1.73	0.750
Hyperhomocysteinemia (n)	1.511	0.72–1.86	0.355
Smoking (n)	1.753	1.05–2.96	0.450
Drinking (n)	1.690	1.24–2.19	0.238
Atrial fibrillation (n)	1.313	0.61–2.42	0.403
Stroke history (n)	0.793	0.51–1.54	0.833
with periventricular WMH	1.597	1.04–4.37	0.369
with subcortical WMH	1.415	1.02–2.37	0.457
with lacunes(n)	1.263	0.75–2.15	0.326
FT3, pmol/L	0.370	0.22–0.54	0.013
FT4, pmol/L	1.027	0.92–1.12	0.573
TSH, uIU/ml	0.836	0.62–1.08	0.201
FT3/FT4	0.001	0.00–0.01	0.001
NIHSS on admission	1.742	1.12–2.34	0.008
Multivariate analysis
Age (years)	1.471	1.22–1.78	0.015
FT3, pmol/L	0.348	0.18–0.72	0.007
NIHSS on admission	1.410	1.17–1.85	< 0.001

WMH white matter hyperintensity; FT3 free triiodothyronine; FT4 free thyroxine; TSH thyroid stimulating hormone; NIHSS National Institutes of Health Stroke Scale

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