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Fig. 2 | BMC Neurology

Fig. 2

From: Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis – a community-based randomized controlled trial

Fig. 2

Spirit diagram depicting the schedule of enrolment, interventions and assessments. T0 = baseline assessment before stratified randomization; T1 = collection of blood samples immediately before a training session at midpoint (6 weeks after intervention onset). Biomarkers at T1 will be further used for midpoint follow-up. Blood samples from the control group will be assessed at the German Sport University Cologne without further measurements at T1.1 and T1.2; T1.1 = collection of blood samples after resistance exercises; T1.2 = collection of blood samples immediately after the training session; T2 = assessment of outcomes 48 h after the last exercise session; * primary outcome; ** stratification factors: i) Bioimpedance analysis using lean body mass; ii) Cardiovascular fitness using Wattmax; iii) Muscular strength using h1RMsum

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