Fig. 2

The outcome of brain biopsy. a Hematoxylin and eosin (H&E) stained slide (× 200) shows a diffuse large B-cell lymphoma. The neoplastic cells have a uniform cytological appearance with medium-sized to large lymphoid cells with usually oval to round vesicular nuclei containing fine chromatin. The cytoplasm is usually scant and amphophilic. b Hematoxylin and eosin (H&E) stained slide (× 400) shows large malignant tumor cells with prominent single central nucleoli (star). Malignant cells were not observed in the intravascular space (arrow). (C) CD20 immunostaining (× 400). It shows strong membranous and perinuclear labeling of the malignant cells for CD20