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Table 4 Results of published studies on the association between six genes and ischemic stroke in Morocco

From: Ischemic stroke in Morocco: a systematic review

Study

Cases

Controls

Genes

Mutations

Genotypes

Methods

Odds Ratio 95% (CI)

P value

They, TP et al., 2011 [40]

91

182

MTHFR

C677T

T allele and Stroke

PCR

1.1 (0.59–2.04)

0.303Ω

T allele and atherothrombotic subtype stroke

2.1 (1.17–3.8)

0.012Ω

They, TP et al., 2013 [41]

91

182

MTHFR*

F2

C677T

G20210A

677TT/CC

20210GA/GG

PCR-RFLP

4.99 (1.75–14.2)

5.29 (1.63–17.1)

0.001

0.005

Diakite, B et al., 2014 [39]

165

182

eNOS

G894 T

TT vs. GG + GT Recessive

PCR-RFLP

2,68 (1,08-6,70)

0.034 Δ

GT + TT vs. GG Dominant

1.78 (1,16–2,73)

0.009 Δ

T vs. G Additive models

1.71 (1,21–2,43)

0.003 Δ

Diakite, B et al., 2015 [37]

170

211

FV

C2491T

T allèle

PCR-RFLP

3.77 (2.70–5.25)

< 0.0001**

CT

4.08 (2.55–6.49)

TT

8.95 (4.15–19.29)

Diakite, B et al., 2016 [38]

175

201

APOA5

T1131C

CC

PCR-RFLP

2.86 (1.24–6.58)

0.014

C allele

1.54 (1.01–2.33)

ALOX5AP

SG13S114

TT

PCR-RFLP

2.57 (1.49–4.83)

0.009

T allele

1.59 (1.16–2.19)

0.008

Balar, K et al., 2014 [36]

165

MTHFR

Facteurs de risque

CT/TT

NS ^

  1. PCR-RFLP Polymerase Chain Reaction-Restriction Fragment Length Polymorphism, *Synergistic effect of MTHFR C677T and F2 G20210A polymorphisms on ischemic stroke. Prospective study, Age/Diabetes/High Blood Pressure/Smoking/Alcoholism/ Cholesterol, NS: Not significant, ΩHardy– Weinberg equilibrium tests were performed for MTHFR C677T polymorphism separately among cases and controls with the use of Fisher’s exact test, Univariate analysis for the combined polymorphisms, multivariate analysis for the combined polymorphisms, ΔThe law of the genotype distribution for G894 T eNOS polymorphism among disease cases and controls were performed with Hardy–Weinberg equilibrium test with the use of χ2 test, **Significant; HWE, Hardy–Weinberg equilibrium, Hardy–Weinberg equilibrium test with the use of χ2 test or Fisher test, ^the multivariate analysis (logistic regression)