Table 2 Correlation of genetic epidemiology of the ETFDH C.250G > A mutation and Southern Min Population
Regions and Countries | Southern Min (%)* | SouthernMin (millions) | No. ETFDH MADD cases | c.250G > A mutation (%)* | c.250G > A alleles (No.) | Homozygous cases | Heterozygous cases |
|---|---|---|---|---|---|---|---|
Henan | Origin | – | 9 | 17% | 3 | 0 | 3 |
Chaoshan1 | ~ 90% | ~ 14 m | 2 | 100% | 4 | 2 | 0 |
Fujian1,3 | ~ 60% | ~ 20 m | 58 | 81% | 94 | 40 | 14 |
Taiwan2,3 | ~ 70% | ~ 15.6 m | 19 | 71% | 27 | 10 | 7 |
Hainan1,3 | ~ 59% | ~ 5 m | 1 | 50% | 1 | 0 | 1 |
Singapore2,3 | ~ 37% | ~ 1.86 m | 1 | 50% | 1 | 0 | 1 |
Guangzhou area1,3 | ~ 6% | ~ 3 m | 6 | 42% | 5 | 1 | 3 |
Hong Kong2,3 | ~ 6.7% | ~ 0.5 m | 3 | 17% | 1 | 0 | 1 |
Thailand2,3 | ~ 9% | ~ 5 m | 3 | 50% | 3 | 0 | 3 |
Shanghai areaa 1,3 | ~ 1% | ~ 2 m | 34 | 26% | 18 | 6 | 6 |
Shandonga | < 1% | – | 59 | 4% | 5 | 0 | 5 |
Beijinga | < 1% | – | 57 | 2% | 2 | 0 | 2 |
Other provinces | < 1% | – | 24 | 2% | 1 | 0 | 1 |
Japan | < 1% | – | 16 | 0% | 0 | 0 | 0 |
Korea | < 1% | – | 2 | 0% | 0 | 0 | 0 |
Other Countries1,2,3 | < 1% | ~ 20 m | 87 | 0.6% | 1 | 0 | 1 |
Total | 381 | 169 | 59 | 48 |