Fig. 2From: Multimodal MRI of grey matter, white matter, and functional connectivity in cognitively healthy mutation carriers at risk for frontotemporal dementia and Alzheimer's diseaseWhite matter FA analysis. Differences in FA (or lack thereof) are shown for each contrast (e.g., MAPT/GRN mutation carriers greater or smaller than controls; APOE4 carriers greater or smaller than controls; MAPT/GRN carrier-control differences greater or smaller than APOE4 carrier-control differences). Mean skeleton maps are shown in green; skeletonised significant results were thickened for better visualisation. Four clusters of FA reductions were found in APOE4 carriers compared to controls (middle left panel). Colour bar represents significance. APOE4, apolipoprotein E ε4; FA, fractional anisotropy; MAPT/GRN, microtubule-associated protein tau / progranulinBack to article page