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Table 4 Severity and tolerability of side effects of Myasthenia Gravis treatment (N = 158)1

From: Understanding side effects of therapy for myasthenia gravis and their impact on daily life

Side Effect StatementOverall Severity Sample2Overall Tolerability Sample3Patients who ever experienced side effect4
Severity2Tolerability3
nMean (SD)nMean (SD)nMean (SD)nMean (SD)
1. To gain weight1522.5 (1.1)1422.9 (1.0)1182.9 (0.8)1173.0 (0.9)
2. To have muscle weakness, causing my legs to be unsteady1512.2 (1.0)1362.7 (1.0)1022.7 (0.7)992.8 (1.0)
3. To have low blood pressure1491.3 (0.8)1181.9 (1.0)322.6 (0.8)322.3 (1.0)
4. To lose weight1461.3 (0.7)1131.8 (1.0)282.5 (0.7)271.9 (0.9)
5. To have shortness of breath1452.0 (1.0)1242.7 (1.0)882.7 (0.7)833.0 (0.8)
6. Side effects such as acid reflux, heart burn, indigestion, esophageal ulcers, and irritable bowel syndrome1502.0 (1.1)1342.7 (1.0)902.7 (0.8)882.9 (0.8)
7. Severe side effects such as: aseptic meningitis, sepsis, pneumonia, pleural edema, fluid in the heart, allergic/anaphylactic reactions, or internal bleeding.1491.5 (1.0)1192.6 (1.4)323.3 (0.7)323.3 (1.0)
8. Changes to my skin1502.1 (1.0)1332.5 (1.0)942.7 (0.7)942.7 (0.8)
9. To have headaches or migraines1491.9 (1.0)1292.5 (1.1)792.6 (0.8)792.8 (0.9)
10. Muscle wasting1481.7 (0.8)1222.6 (1.2)662.5 (0.6)652.8 (0.9)
11. Vision changes, such as double vision1482.1 (1.1)1272.7 (1.0)882.8 (0.8)882.9 (0.9)
12. Watery eyes, increased saliva, nasal drainage, secretions, or mucus1492.1 (1.0)1342.4 (0.9)1012.7 (0.7)992.6 (0.8)
13. To be fatigued. I felt weak, tired, drained1492.4 (1.0)1282.8 (0.9)1162.8 (0.7)1073.0 (0.8)
14. Side effects such as constipation, stomach cramps, intestinal pain and cramping, stomach bloating, and gas1482.2 (1.0)1342.7 (0.9)1062.7 (0.7)1042.8 (0.8)
15. To become forgetful, confused, and have problems concentrating1471.8 (0.9)1222.6 (1.0)792.6 (0.7)782.8 (0.9)
16. To have mood changes1482.1 (1.0)1302.7 (1.1)952.7 (0.8)942.9 (1.0)
17. To have fluid retention1461.7 (0.9)1222.5 (1.0)662.6 (0.7)652.7 (0.9)
18. To have heart problems1471.6 (0.9)1212.5 (1.2)532.6 (0.8)512.9 (1.0)
19. Changes to my laboratory values (blood tests)1491.9 (0.9)1292.3 (1.0)872.5 (0.7)852.5 (0.9)
20. My extremities (toes, fingers) to become tingly and sensitive to the cold1461.6 (0.8)1222.3 (1.0)652.4 (0.7)652.7 (0.8)
21. A mild allergic reaction such as hives or rashes1451.4 (0.7)1172.1 (1.0)462.3 (0.6)462.4 (0.8)
22. To have diarrhea1482.4 (1.1)1332.7 (1.0)1072.9 (0.8)1042.9 (0.9)
23. My face to bloat or swell1472.0 (1.0)1322.5 (1.0)852.7 (0.7)822.7 (0.9)
24. Feel lightheaded or dizzy1451.7 (0.8)1242.4 (1.0)732.4 (0.6)722.7 (0.7)
25. To become depressed, anxious, or nervous1462.0 (1.0)1262.6 (1.0)852.7 (0.8)842.9 (0.9)
26. Decreased my immune response1482.1 (1.0)1332.8 (1.0)952.7 (0.8)913.1 (0.7)
27. To develop other medical conditions1451.6 (0.9)1292.7 (1.3)532.7 (0.8)543.1 (1.0)
28. To become infertile1441.0 (0.3)1082.0 (1.3)32.7 (1.2)42.5 (1.3)
29. To have muscle cramps in my legs1502.2 (0.9)1372.6 (0.9)1132.6 (0.8)1112.7 (0.8)
30. Aches and pain in various parts of my body1461.9 (0.9)1252.4 (0.9)862.6 (0.7)832.7 (0.8)
31. To have nausea and/or vomiting.1461.6 (0.9)1192.4 (1.1)612.5 (0.7)602.8 (0.7)
32. Muscle twitching and eye twitching or eyelid drooping.1492.0 (1.0)1312.5 (0.9)932.6 (0.8)922.7 (0.7)
33. To have hot flashes and to sweat profusely1491.8 (0.9)1242.4 (1.0)802.5 (0.7)772.6 (0.8)
34. Develop blood clots1441.2 (0.7)1122.4 (1.4)113.5 (0.8)113.9 (0.3)
35. High blood pressure1431.5 (0.8)1212.3 (1.2)482.5 (0.7)502.7 (1.0)
  1. 1Four participants did not complete the demographic section in Part 1, but completed Part 2
  2. 2Severity was assessed on a 1–4 scale, with 1 being “have not experienced this side effect” and 4 being “very severe”
  3. 3Tolerability was assessed on a 1–4 scale, with 1 being “very tolerable” and 4 being “not at all tolerable”
  4. 4Patients who rated side effect as a “2-Mildly severe” or higher