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Table 1 Characteristics of studies included in Meta-analysis of overall MS

From: Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis

Study authorYearCountryEthnicitySex cases/controlsTotal cases/controlAge case/control (Mean)Genotyping methodQuality score
FokI (rs2228570)
 Partridge et al.2004UKEuropeanM = NR F=NR406 /23443.8 ± 11.2 / 50.1NR7
 Tajouri et al.2005AustraliaAustralianM = NR F=NR98 / 93NRPCR–RFLP6
  Smolders et al.2009NetherlandEuropeanM = 62/ 142 F = 150/ 147212 / 28946.7 ± 11.9 /34.9 ± 14.3PCR–RFLP8
 Dickinson et al.2009AustraliaAustralianM = NR F=NR136 / 23543.5 ± 9.3/ 43.6 ± 9.2Taq-Man7
 Simon et al.2010USAAmericanM = NR F=NR100 / 100NRTaq-Man7
 Garcia-Martin et al.2013SpainEuropeanM = 94/ 98 F = 209/ 212303 / 31043.9 ± 11.4/ 43.4 ± 11.7Taq-Man8
 Al-Temaimi et al.2015KuwaitAsianM = 17/ 19 F = 33/ 3150 / 5033.4 ± 9.6/ 28.6 ± 7.9Taq-Man7
 Narooie-Nejad et al.2015IranAsianM = 25 / 28 F = 88/ 94113 / 12232.4 ± 8.9/ 30.8 ± 10.2PCR–RFLP7
 Cierny et al.2015SlovakiaEuropeanM = 66 / 74 F = 204 / 229270 / 30341.3 ± 10.8/ 38.7 ± 13.6PCR–RFLP8
 Luisa Agnello et al.2016ItalyEuropeanM = 24 / 30 F = 80 / 42104 / 7539.6 ± 10.3/ 45.2 ± 9.36PCR–RFLP6
 Abdollahzadeh et al.2016IranAsianM = 40 / 38 F = 120 / 112160 / 15035.9 ± 3 / 36.8 ± 1.8PCR–RFLP7
 Yucel et al.2017TurkeyEuropeanM = NRF=NR29 / 11433.7 ± 10.7 / 33.1 ± 8.5Taq-Man6
 Bettencourt et al.2017PortugalEuropeanM = 185/198 F = 348/248533 / 44630.2 ± 9.3/ NRTaq-Man8
 Kamisli et al.2018TurkeyEuropeanM = 46 / 58 F = 121 / 88167 / 14639.96 ± 9.4 / 33.81 ± 7.1Taq-Man7
 Sadeghi et al.2018IranAsianM = 17/11 F = 63/3980 / 5018–60/ 18–60PCR–RFLP6
 Křenek et al.2018Czech RepublicEuropeanM = 80/49 F = 216/86296/13534–37 / NRPCR–RFLP7
TaqI (rs731236)
 Partridge et al.2004UKEuropeanM = NR F=NR402 /23143.8 ± 11.2 / 50.1NR7
 Tajouri et al.2005AustraliaAustralianM = NR F=NR104 / 186NRPCR–RFLP6
 Smolders et al.2009NetherlandEuropeanM = 62/ 142 F = 150/ 147212 / 28946.7 ± 11.9 /34.9 ± 14.3PCR–RFLP8
 Dickinson et al.2009AustraliaAustralianM = NR F=NR136 / 23543.5 ± 9.3/ 43.6 ± 9.2Taq-Man7
 Simon et al.2010USAAmericanM = NR F=NR100 / 100NRTaq-Man7
 Sioka et al.2011GreeceEuropeanM = 23/ 23 F = 46/ 5869 / 8139 ± 10.5/38.7 ± 10.7Taq-Man7
 Agliardi et al.2011ItalyEuropeanM = NR F=NR641 / 55827.8 ± 9.2/ 29.4 ± 6.5Taq-Man8
 Irizar et al.2012SpainEuropeanM = NR F=NR136 / 33744.14 ± 13.02/ 50.17 ± 13.26PCR-SSP7
 Garcia-Martin et al.2013SpainEuropeanM = 94/ 98 F = 209/ 212303 / 31043.9 ± 11.4/ 43.4 ± 11.7Taq-Man8
 Selma et al.2015TunisiaAfricanM = 22/ 47 F = 38/ 6760 / 11435.8 ± 6.3 / 37 ± 9.3PCR–RFLP6
 Narooie-Nejad et al.2015IranAsianM = 25 / 28 F = 88/ 94113 / 12232.4 ± 8.9/ 30.8 ± 10.2PCR–RFLP7
 Al-Temaimi et al.2015KuwaitAsianM = 17/ 19 F = 33/ 3150 / 5033.4 ± 9.6/ 28.6 ± 7.9Taq-Man7
 Yamout et al.2016LebanonAsianM = NR F=NR50 / 9932.3 ± 12.7 / 35.2 ± 13PCR–RFLP6
 Cierny et al.2016SlovakiaEuropeanM = 66 / 74 F = 204 / 229270 / 30341.3 ± 10.8/ 38.7 ± 13.6PCR–RFLP8
 Luisa Agnello et al.2016ItalyEuropeanM = 24 / 30 F = 80 / 42104 / 7539.6 ± 10.3/ 45.2 ± 9.36PCR–RFLP6
 Terzi et al.2016TurkeyEuropeanM = NR F=NR87 / 9930.14 9.66/ NRPCR–RFLP6
 Abdollahzadeh et al.2016IranAsianM = 40 / 38 F = 120 / 112160 / 15035.9 ± 3 / 36.8 ± 1.8PCR–RFLP7
 Yucel et al.2017TurkeyEuropeanM = NR F=NR28 / 7233.7 ± 10.7 / 33.1 ± 8.5Taq-Man6
 Kamisli et al.2018TurkeyEuropeanM = 46 / 58 F = 121 / 88167 / 14639.96 ± 9.4 / 33.81 ± 7.1Taq-Man7
 Morales et al.2018MexicoAmericanM = 39/ 57 F = 81/123120 / 18033.89 ± 10.03/ 32.79 ± 10.17Taq-Man6
 Sadeghi et al.2018IranAsianM = 17/11 F = 63/3980 / 5018–60/ 18–60PCR–RFLP6
 Cakina et al..2018TurkeyEuropeanM = 19/22 F = 51/4870 / 7044.4 ± 11.2 / 38.2 ± 9.5PCR–RFLP7
 Křenek et al.2018Czech RepublicEuropeanM = 80/49 F = 216/86296 / 13534–37 / NRPCR–RFLP7
BsmI (rs1544410)
 Fukazawa et al.1999JapanAsianM = 21/33 F = 56/6277 / 9534.9 ± 12.9/NRPCR–RFLP8
 Qinli Sun et al.2004ChinaAsianM = NR F=NR63 / 95NRPCR–RFLP6
 Bing Wu et al.2009ChinaAsianM = NR F=NR83 / 120NRPCR–RFLP7
 Simon et al.2010USAAmericanM = NR F=NR101 / 100NRTaq-Man7
 Sioka et al.2011GreeceEuropeanM = 23/ 23 F = 46/ 5869 / 8139 ± 10.5/38.7 ± 10.7Taq-Man7
 Al-Temaimi et al.2015KuwaitAsianM = 17/ 19 F = 33/ 3150 / 5033.4 ± 9.6/ 28.6 ± 7.9Taq-Man7
 Narooie-Nejad et al.2015IranAsianM = 25 / 28 F = 88/ 94113 / 12232.4 ± 8.9/ 30.8 ± 10.2PCR–RFLP7
 Abdollahzadeh et al.2016IranAsianM = 40 / 38 F = 120 / 112160 / 15035.9 ± 3 / 36.8 ± 1.8PCR–RFLP7
 Yamout et al.2016LebanonAsianM = NR F=NR50 / 9932.3 ± 12.7 / 35.2 ± 13PCR–RFLP6
 Cierny et al.2016SlovakiaEuropeanM = 66 / 74 F = 204 / 229270 / 30341.3 ± 10.8/ 38.7 ± 13.6PCR–RFLP8
 Luisa Agnello et al.2016ItalyEuropeanM = 24 / 30 F = 80 / 42104 / 7539.6 ± 10.3/ 45.2 ± 9.36PCR–RFLP6
 Terzi et al.2016TurkeyEuropeanM = NR F=NR87 / 10030.14 ± 9.66/ NRPCR–RFLP6
 Morales et al.2017MexicoAmericanM = 39/ 57 F = 81/123120 / 18033.89 ± 10.03/ 32.79 ± 10.17Taq-Man6
 Sadeghi et al.2018IranAsianM = 17/11 F = 63/3980 / 5018–60/ 18–60PCR–RFLP6
 Cakina et al..2018TurkeyEuropeanM = 19/22 F = 51/4870 / 7044.4 ± 11.2 / 38.2 ± 9.5PCR–RFLP7
 Křenek et al.2018Czech RepublicEuropeanM = 80/49 F = 216/86296 / 13534–37 / NRPCR–RFLP7
ApaI (rs7975232)
 Niino et al.2000JapanAsianM = 21 / 33 F = 56 / 6277 / 9536.2 ± 11.2 / 34.4 ± 10.2PCR–RFLP7
 Qinli Sun et al.2004ChinaAsianM = NR F=NR63 / 95NRPCR–RFLP6
 Tajouri et al.2005AustraliaAustralianM = NR F=NR104 / 100NRPCR–RFLP6
 Smolders et al.2009NetherlandEuropeanM = 62/ 142 F = 150/ 147212 / 28946.7 ± 11.9 /34.9 ± 14.3PCR–RFLP8
 Bing Wu et al.2009ChinaAsianM = NR F=NR83 / 120NRPCR–RFLP7
 Simon et al.2010USAAmericanM = NR F=NR100 / 100NRTaq-Man7
Irizar et al.2012SpainEuropeanM = NR F=NR134 / 34044.14 ± 13.02/ 50.17 ± 13.26PCR-SSP7
 Narooie-Nejad et al.2015IranAsianM = 25 / 28 F = 88/ 94113 / 12232.4 ± 8.9/ 30.8 ± 10.2PCR–RFLP7
 Al-Temaimi et al.2015KuwaitAsianM = 17/ 19 F = 33/ 3150 / 5033.4 ± 9.6/ 28.6 ± 7.9Taq-Man7
 Selma et al.2015TunisiaAfricanM = 22/ 47 F = 38/ 6760 / 11435.8 ± 6.3 / 37 ± 9.3PCR–RFLP6
 Yamout et al.2016LebanonAsianM = NR F=NR50 / 13432.3 ± 12.7 / 35.2 ± 13PCR–RFLP6
 Luisa Agnello et al.2016ItalyEuropeanM = 24 / 30 F = 80 / 42104 / 7539.6 ± 10.3/ 45.2 ± 9.36PCR–RFLP6
 Abdollahzadeh et al.2016IranAsianM = 40 / 38 F = 120 / 112160 / 15035.9 ± 3 / 36.8 ± 1.8PCR–RFLP7
 Cierny et al.2016SlovakiaEuropeanM = 66 / 74 F = 204 / 229270 / 30341.3 ± 10.8/ 38.7 ± 13.6PCR–RFLP8
 Terzi et al.2016TurkeyEuropeanM = NR F=NR87 / 10030.14 9.66/ NRPCR–RFLP6
 Yucel et al.2017TurkeyEuropeanM = NR F=NR26 / 8133.7 ± 10.7 / 33.1 ± 8.5Taq-Man6
 Kamisli et al.2018TurkeyEuropeanM = 46 / 58 F = 121 / 88167 / 14639.96 ± 9.4 / 33.81 ± 7.1Taq-Man8
 Sadeghi et al.2018IranAsianM = 17/11 F = 63/3980 / 5018–60/ 18–60PCR–RFLP7
 Cakina et al..2018TurkeyEuropeanM = 19/22 F = 51/4870 / 7044.4 ± 11.2 / 38.2 ± 9.5PCR–RFLP7
 Křenek et al.2018Czech RepublicEuropeanM = 80/49 F = 216/86296 / 13534–37 / NRPCR–RFLP7
  1. NR not reported, M male, F female, MS Multiple Sclerosis