Skip to main content

Table 3 Main results of pooled ORs in meta-analysis of Vitamin D Receptor Gene Polymorphisms

From: Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis

Subgroup Sample sizeTest of associationTest of heterogeneityTest of publication bias (Begg’s test)Test of publication bias (Egger’s test)
Genetic modelCase/ControlOR95% CII2 (%)PZPTP
FokI (rs2228570)
 OverallDominant model3057 / 28521.060.94–1.1945.70.02−1.440.15−1.090.29
Recessive model3057 / 28520.960.81–1.1323.80.140.780.450.130.90
Allelic model3057 / 28521.080.93–1.2666.6≤0.0010.630.520.460.65
ff vs. FF3057 / 28520.960.80–1.1648.40.010.050.96−0.630.54
Ff vs.FF3057 / 28521.060.93–1.1926.40.16−1.440.15−1.330.20
 EuropeanDominant model2480 / 22021.100.97–1.2641.70.08−1.160.24−0.620.55
Recessive model2480 / 22020.960.80–1.1538.10.101.160.240.200.84
Allelic model2480 / 22021.040.90–1.2056.50.010.270.78−0.320.75
ff vs. FF2480 / 22021.000.75–1.3342.80.070.270.78−0.170.86
Ff vs.FF2480 / 22021.110.97–1.2824.90.210.270.780.240.81
 AsianDominant model243 / 2221.050.68–1.6170.90.03−0.520.60−0.860.54
Recessive model243 / 2221.270.21–7.6157.90.12−10.31**
Allelic model243 / 2221.060.46–2.4580.9≤0.001−0.520.60−0.360.77
ff vs. FF243 / 2220.510.02–14.1840.0110.31**
Ff vs. FF243 / 2220.930.60–1.4543.50.17−0.520.60−1.020.42
TaqI (rs731236)
 OverallDominant model3758/39921.260.99–1.6080.5≤0.001−0.130.890.380.71
Recessive model3758/39920.190.91–1.5763≤0.0011.750.081.460.16
Allelic model3758/39921.160.94–1.4287.2≤0.001−0.870.380.240.81
 tt vs. TT3758/39921.260.93–1.7165.9≤0.0010.540.580.980.34
Tt vs.TT3758/39921.271.01–1.5974.5≤0.001−0.500.610.430.67
 EuropeanDominant model2785 / 27061.110.99–1.2500.90−0.800.420.080.94
Recessive model2785 / 27061.040.88–1.2300.631.170.241.140.27
Allelic model2785 / 27061.060.97–1.1500.76−1.550.120.050.96
tt vs. TT2785 / 27061.110.92–1.3300.820.630.520.980.34
Tt vs.TT2785 / 27061.120.99–1.2700.79−0.720.47−0.080.94
 AsianDominant model453 / 4711.530.34–6.9595≤0.001−0.980.32−0.240.82
Recessive model453 / 4712.980.55–16.284.4≤0.001010.220.84
Allelic model453 / 4711.430.40–5.1396.9≤0.001−1.960.05−0.590.59
tt vs. TT453 / 4714.130.41–41.890.5≤0.001010.180.87
Tt vs.TT453 / 4711.310.38–4.5491.7≤0.001−0.980.32−0.250.81
BsmI(rs1544410)
 Dominant model1793 / 18150.840.48–1.4991.3≤0.001−0.240.801.810.09
Recessive model1793 / 18151.300.92–1.8562.9≤0.0010.930.351.670.12
Allelic model1793 / 18151.100.89–1.3769.7≤0.0010.180.850.230.82
bb vs. BB1793 / 18151.240.78–1.9964.9≤0.001−1.950.05−0.550.59
Bb vs.BB1793 / 18151.150.96–1.3749.60.02−1.460.14−1.650.12
 EuropeanDominant model896 / 7640.620.25–1.5593.3≤0.001−0.190.851.500.2
Recessive model896 / 7640.840.65–1.0900.661.470.141.840.16
Allelic model896 / 7640.990.85–1.1600.51−0.940.34−1.450.22
bb vs. BB896 / 7641.070.76–1.5000.46−1.960.05−1.290.28
Bb vs.BB896 / 7641.080.72–1.6254.10.05−0.940.34−2.340.07
 AsianDominant model676 / 7711.090.54–2.2278.5≤0.00101−0.300.78
Recessive model676 / 7711.781.08–2.9344.20.09−1.350.17−1.010.35
Allelic model676 / 7711.280.81–2.0279≤0.001−0.490.690.260.80
bb vs. BB676 / 7711.500.46–4.8876.3≤0.001−1.360.17−0.970.43
Bb vs.BB676 / 7711.080.59–1.9666.90.01−0.490.62−0.120.91
ApaI (rs7975232)
 Dominant model2306 / 26691.040.82–1.3158≤0.001−1.230.21−1.140.26
Recessive model2306 / 26690.830.66–1.0551≤0.001−0.580.55−0.570.57
Allelic model2306 / 26690.940.80–1.1068.2≤0.001−0.550.58−1.020.32
aa vs. AA2306 / 26690.850.63–1.1655.1≤0.001−0.780.43−1.260.22
Aa vs. AA2306 / 26691.200.88–1.6472.2≤0.001−0.970.33−0.640.53
 EuropeanDominant model1366 / 15391.130.87–1.4749.80.04010.210.84
Recessive model1366 / 15391.010.78–1.3338.70.11−0.420.67−0.490.64
Allelic model1366 / 15391.050.88–1.2453.60.0201−0.560.59
aa vs. AA1366 / 15391.110.76–1.6356.90.010.830.400.060.95
Aa vs. AA1366 / 15391.410.86–2.3181.4≤0.0010.830.400.520.61
 AsianDominant model676 / 8160.870.49–1.5370.9≤0.001−1.730.08−2.670.03
Recessive model676 / 8160.610.42–0.8940.40.110.990.320.640.54
Allelic model676 / 8160.810.57–1.1576.1≤0.0011.370.170.690.51
aa vs. AA676 / 8160.520.32–0.86280.200.250.800.370.72
Aa vs. AA676 / 8161.030.59–1.7964.5≤0.001−2.230.02−2.170.07
  1. The significant values are presented with boldface