Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis

Imani, Danyal; Razi, Bahman; Motallebnezhad, Morteza; Rezaei, Ramazan

doi:10.1186/s12883-019-1577-y

Table 3 Main results of pooled ORs in meta-analysis of Vitamin D Receptor Gene Polymorphisms

From: Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis

Subgroup		Sample size	Test of association		Test of heterogeneity		Test of publication bias (Begg’s test)		Test of publication bias (Egger’s test)
Subgroup	Genetic model	Case/Control	OR	95% CI	I² (%)	P	Z	P	T	P
FokI (rs2228570)
Overall	Dominant model	3057 / 2852	1.06	0.94–1.19	45.7	0.02	−1.44	0.15	−1.09	0.29
	Recessive model	3057 / 2852	0.96	0.81–1.13	23.8	0.14	0.78	0.45	0.13	0.90
	Allelic model	3057 / 2852	1.08	0.93–1.26	66.6	≤0.001	0.63	0.52	0.46	0.65
	ff vs. FF	3057 / 2852	0.96	0.80–1.16	48.4	0.01	0.05	0.96	−0.63	0.54
	Ff vs.FF	3057 / 2852	1.06	0.93–1.19	26.4	0.16	−1.44	0.15	−1.33	0.20
European	Dominant model	2480 / 2202	1.10	0.97–1.26	41.7	0.08	−1.16	0.24	−0.62	0.55
	Recessive model	2480 / 2202	0.96	0.80–1.15	38.1	0.10	1.16	0.24	0.20	0.84
	Allelic model	2480 / 2202	1.04	0.90–1.20	56.5	0.01	0.27	0.78	−0.32	0.75
	ff vs. FF	2480 / 2202	1.00	0.75–1.33	42.8	0.07	0.27	0.78	−0.17	0.86
	Ff vs.FF	2480 / 2202	1.11	0.97–1.28	24.9	0.21	0.27	0.78	0.24	0.81
Asian	Dominant model	243 / 222	1.05	0.68–1.61	70.9	0.03	−0.52	0.60	−0.86	0.54
	Recessive model	243 / 222	1.27	0.21–7.61	57.9	0.12	−1	0.31	*	*
	Allelic model	243 / 222	1.06	0.46–2.45	80.9	≤0.001	−0.52	0.60	−0.36	0.77
	ff vs. FF	243 / 222	0.51	0.02–14.1	84	0.01	1	0.31	*	*
	Ff vs. FF	243 / 222	0.93	0.60–1.45	43.5	0.17	−0.52	0.60	−1.02	0.42
TaqI (rs731236)
Overall	Dominant model	3758/3992	1.26	0.99–1.60	80.5	≤0.001	−0.13	0.89	0.38	0.71
	Recessive model	3758/3992	0.19	0.91–1.57	63	≤0.001	1.75	0.08	1.46	0.16
	Allelic model	3758/3992	1.16	0.94–1.42	87.2	≤0.001	−0.87	0.38	0.24	0.81
	tt vs. TT	3758/3992	1.26	0.93–1.71	65.9	≤0.001	0.54	0.58	0.98	0.34
	Tt vs.TT	3758/3992	1.27	1.01–1.59	74.5	≤0.001	−0.50	0.61	0.43	0.67
European	Dominant model	2785 / 2706	1.11	0.99–1.25	0	0.90	−0.80	0.42	0.08	0.94
	Recessive model	2785 / 2706	1.04	0.88–1.23	0	0.63	1.17	0.24	1.14	0.27
	Allelic model	2785 / 2706	1.06	0.97–1.15	0	0.76	−1.55	0.12	0.05	0.96
	tt vs. TT	2785 / 2706	1.11	0.92–1.33	0	0.82	0.63	0.52	0.98	0.34
	Tt vs.TT	2785 / 2706	1.12	0.99–1.27	0	0.79	−0.72	0.47	−0.08	0.94
Asian	Dominant model	453 / 471	1.53	0.34–6.95	95	≤0.001	−0.98	0.32	−0.24	0.82
	Recessive model	453 / 471	2.98	0.55–16.2	84.4	≤0.001	0	1	0.22	0.84
	Allelic model	453 / 471	1.43	0.40–5.13	96.9	≤0.001	−1.96	0.05	−0.59	0.59
	tt vs. TT	453 / 471	4.13	0.41–41.8	90.5	≤0.001	0	1	0.18	0.87
	Tt vs.TT	453 / 471	1.31	0.38–4.54	91.7	≤0.001	−0.98	0.32	−0.25	0.81
BsmI(rs1544410)
	Dominant model	1793 / 1815	0.84	0.48–1.49	91.3	≤0.001	−0.24	0.80	1.81	0.09
	Recessive model	1793 / 1815	1.30	0.92–1.85	62.9	≤0.001	0.93	0.35	1.67	0.12
	Allelic model	1793 / 1815	1.10	0.89–1.37	69.7	≤0.001	0.18	0.85	0.23	0.82
	bb vs. BB	1793 / 1815	1.24	0.78–1.99	64.9	≤0.001	−1.95	0.05	−0.55	0.59
	Bb vs.BB	1793 / 1815	1.15	0.96–1.37	49.6	0.02	−1.46	0.14	−1.65	0.12
European	Dominant model	896 / 764	0.62	0.25–1.55	93.3	≤0.001	−0.19	0.85	1.50	0.2
	Recessive model	896 / 764	0.84	0.65–1.09	0	0.66	1.47	0.14	1.84	0.16
	Allelic model	896 / 764	0.99	0.85–1.16	0	0.51	−0.94	0.34	−1.45	0.22
	bb vs. BB	896 / 764	1.07	0.76–1.50	0	0.46	−1.96	0.05	−1.29	0.28
	Bb vs.BB	896 / 764	1.08	0.72–1.62	54.1	0.05	−0.94	0.34	−2.34	0.07
Asian	Dominant model	676 / 771	1.09	0.54–2.22	78.5	≤0.001	0	1	−0.30	0.78
	Recessive model	676 / 771	1.78	1.08–2.93	44.2	0.09	−1.35	0.17	−1.01	0.35
	Allelic model	676 / 771	1.28	0.81–2.02	79	≤0.001	−0.49	0.69	0.26	0.80
	bb vs. BB	676 / 771	1.50	0.46–4.88	76.3	≤0.001	−1.36	0.17	−0.97	0.43
	Bb vs.BB	676 / 771	1.08	0.59–1.96	66.9	0.01	−0.49	0.62	−0.12	0.91
ApaI (rs7975232)
	Dominant model	2306 / 2669	1.04	0.82–1.31	58	≤0.001	−1.23	0.21	−1.14	0.26
	Recessive model	2306 / 2669	0.83	0.66–1.05	51	≤0.001	−0.58	0.55	−0.57	0.57
	Allelic model	2306 / 2669	0.94	0.80–1.10	68.2	≤0.001	−0.55	0.58	−1.02	0.32
	aa vs. AA	2306 / 2669	0.85	0.63–1.16	55.1	≤0.001	−0.78	0.43	−1.26	0.22
	Aa vs. AA	2306 / 2669	1.20	0.88–1.64	72.2	≤0.001	−0.97	0.33	−0.64	0.53
European	Dominant model	1366 / 1539	1.13	0.87–1.47	49.8	0.04	0	1	0.21	0.84
	Recessive model	1366 / 1539	1.01	0.78–1.33	38.7	0.11	−0.42	0.67	−0.49	0.64
	Allelic model	1366 / 1539	1.05	0.88–1.24	53.6	0.02	0	1	−0.56	0.59
	aa vs. AA	1366 / 1539	1.11	0.76–1.63	56.9	0.01	0.83	0.40	0.06	0.95
	Aa vs. AA	1366 / 1539	1.41	0.86–2.31	81.4	≤0.001	0.83	0.40	0.52	0.61
Asian	Dominant model	676 / 816	0.87	0.49–1.53	70.9	≤0.001	−1.73	0.08	−2.67	0.03
	Recessive model	676 / 816	0.61	0.42–0.89	40.4	0.11	0.99	0.32	0.64	0.54
	Allelic model	676 / 816	0.81	0.57–1.15	76.1	≤0.001	1.37	0.17	0.69	0.51
	aa vs. AA	676 / 816	0.52	0.32–0.86	28	0.20	0.25	0.80	0.37	0.72
	Aa vs. AA	676 / 816	1.03	0.59–1.79	64.5	≤0.001	−2.23	0.02	−2.17	0.07

The significant values are presented with boldface

Back to article page

ISSN: 1471-2377

Contact us

General enquiries: journalsubmissions@springernature.com

BMC Neurology

Contact us