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Table 1 Socio-demographic and clinical characteristics by AT(N) biomarker profiles (n = 129)

From: Cerebro-spinal fluid biomarker levels: phosphorylated tau (T) and total tau (N) as markers for rate of progression in Alzheimer’s disease

 A+ T– (N)– (n = 58, 45%)A+ T+ (N)– (n = 12, 9%)A+ T– (N)+ (n = 17, 13%)A+ T+ (N)+ (n = 42, 33%)p value
Variablen/%n/%n/%n/% 
Female sex34/59%10/83%14/82%30/71%0.139
Carrier of the APOE ε4 allele41/71%8/67%10/59%34/81%0.340
Type of ChEI agent    0.445
 Donepezil (n = 71)37/64%8/67%7/41%19/45% 
 Rivastigmine (n = 24)9/15%1/8%4/24%10/24% 
 Galantamine (n = 34)12/21%3/25%6/35%13/31% 
VariableMean ± standard deviationp value
Estimated age at onset, years72.9 ± 7.274.5 ± 4.877.1 ± 5.770.3 ± 6.20.003
Estimated duration of AD at baseline, years3.2 ± 2.42.3 ± 1.42.2 ± 1.33.0 ± 1.90.228
Age at baseline, years76.1 ± 6.276.8 ± 4.679.2 ± 6.273.3 ± 6.00.005
Education, years10.2 ± 3.19.4 ± 1.99.1 ± 2.09.0 ± 2.00.116
MMSE score at baseline21.7 ± 3.819.5 ± 3.720.6 ± 4.620.2 ± 4.00.181
ADAS-cog score (0–70) at baseline20.8 ± 9.121.8 ± 9.920.6 ± 10.223.2 ± 9.30.633
IADL score at baseline17.2 ± 5.714.6 ± 5.915.9 ± 5.715.9 ± 4.90.403
PSMS score at baseline7.9 ± 2.97.2 ± 1.98.3 ± 3.17.4 ± 2.20.568
Number of concomitant medications at baseline3.5 ± 2.83.3 ± 3.63.5 ± 2.82.6 ± 2.10.335
42, ng/ml122 ± 22116 ± 12118 ± 19115 ± 140.274
T-tau, ng/ml72 ± 1582 ± 11122 ± 19155 ± 46< 0.001
P-tau, ng/ml30 ± 1361 ± 840 ± 979 ± 24< 0.001
  1. Abbreviations: A+ abnormal CSF Aβ42; 42 amyloid-β1–42; AD Alzheimer’s disease; ADAS-cog Alzheimer’s Disease Assessment Scale-cognitive subscale; APOE, apolipoprotein E; ChEI cholinesterase inhibitor; IADL Instrumental Activities of Daily Living scale; MMSE Mini-Mental State Examination; (N)– normal CSF T-tau; (N)+ abnormal CSF T-tau; PSMS Physical Self-Maintenance Scale; P-tau phosphorylated tau; T– normal CSF P-tau; T+ abnormal CSF P-tau; T-tau total tau