Table 1 Continuous variables are shown as mean ± SD, NIHSS and Age are shown as median and IQR, and categorical variables are shown as total (percent). DWI indicated diffusion-weighted imaging; NIHSS, National Institute of Health Stroke Scale; PWI, Perfusion-weighted Imaging; tPA, tissue-type plasminogen activator
From: Blood-brain barrier integrity of stroke patients presenting in an extended time window
All Patients (N = 222) | < 20% Permeability (N = 129) | > 20% Permeability (N = 93) | Univariate Analysis | Multivariate Analysis | |
|---|---|---|---|---|---|
Mean Permeability Derangement (%) | 27.97 | 12.45 | 49.45 | – | |
Age (median) | 73 (59–85) | 69 (58–83) | 76(64–86) | p = 0.031 | p = 0.019 |
Sex (%) | 54.5 | 51.9 | 57.4 | p = 0.238 | |
NIHSS (median) | 6 (0–14) | 6 (3–13) | 6(2–14) | p = 0.695 | |
PWI Volume (mL) | 18.5 (4.3–69.56) | 26.43 (8.9–83.72) | 10.42 (2.7–41.55) | p = 0.012 | p = 0.007 |
DWI Volume (mL) | 2.95 (0.5–9.13) | 5.1 (0.82–11.19) | 1.132 (0.3383–6.86) | p = 0.24 | |
Last Seen Normal to MRI (minutes) | 677 ± 303.5 | 681 ± 300.32 | 670 ± 309.50 | p = 0.781 | |
Found with Symptoms to MRI (minutes) | 364 ± 302.65 | 389 ± 330.05 | 327 ± 356.10 | p = 0.138 | |
Approximate Onset to MRI (minutes) | 511 ± 275.6 | 531 ± 287.50 | 482 ±257 | p = 0.195 |