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Table 1 Clinical features in FOSMN patients with a taste disorder

From: Taste disorder in facial onset sensory and motor neuronopathy: a case report

Patient

Age at onset, y/sex

Initial symptoms

Clinical course

Autoantibodies

Response to treatments

Reference

Present case

49/M

Taste disorder

Weakness of the upper limbs at age of 55

Mechanical ventilation and tube feeding at age of 58

(−)

No response to IVIG

 

1

42/M

Taste disorder

Perioral paresthesia and numbness

Weakness of the neck and shoulder girdles at the age of 50

Tube feeding at the age of 51

Died at the age of 52 due to pulmonary embolism

(+), Anti-sulfatide antibody

No response to PDN,

AZA and MMF

[10]

2

63/F

Facial paresthesia

NA

(−)

A part of patients 2–8 were treated with IVIG, but none of them responded to the treatment.

[18]

3

44/F

Facial paresthesia

NA

(−)

[18]

4

40/M

Dysarthria

NA

(−)

[18]

5

41/M

Facial paresthesia and weakness

NA

(−)

[18]

6

62/F

Facial paresthesia and weakness

NA

(−)

[18]

7

50/F

Facial and upper limbs’ paresthesia and weakness

NA

(−)

[18]

8

51/M

Facial paresthesia and weakness

Weakness of upper limbs

NA

(−)

[18]

  1. IVIG intravenous immunoglobulin, PDN prednisone, AZA azathioprine, MMF mycophenolate mofetil