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Table 4 Comparisons of serum α-synuclein and cytokines between epilepsy, acquired demyelinating disorders of CNS and controls

From: Serum α-synuclein and IL-1β are increased and correlated with measures of disease severity in children with epilepsy: potential prognostic biomarkers?

Serum levelsControl (N = 146)Epilepsy (N = 115)p-valueAcquired demyelinating ds (N = 18)p-value
α-Synuclein (ng/ml)8.0 ± 4.39.5 ± 5.00.0160*11.2 ± .5.90.0250*
IFN-β (pg/ml)397.5 ± 312.3475.5 ± 333.80.0646814.9 ± 1227.30.4672
IFN-γ (pg/ml)3.5 ± 9.34.6 ± 13.10.17186.1 ± 18.50.5644
IL-1β (pg/ml)0.5 ± 1.03.5 ± 13.90.10380.4 ± 0.70.3141
IL-6 (pg/ml)0.9 ± 1.44.2 ± 11.80.0052*7.0 ± 15.50.1833
IL-10 (pg/ml)4.0 ± 9.99.2 ± 20.9< 0.0001**17.7 ± 34.90.0120*
TNF-α (pg/ml)10.2 ± 6.314.3 ± 14.80.0475*12.1 ± 11.60.3959
  1. Data, mean ± standard deviation; CNS, central nervous system; Acquired demyelinating ds, acquired demyelinating disorders of the central nervous system; IFN, interferon; IL, interleukin; TNF, tumor necrosis factor; *p < 0.05, **p < 0.001