Serum α-synuclein and IL-1β are increased and correlated with measures of disease severity in children with epilepsy: potential prognostic biomarkers?

Table 4 Comparisons of serum α-synuclein and cytokines between epilepsy, acquired demyelinating disorders of CNS and controls

Serum levels	Control (N = 146)	Epilepsy (N = 115)	p-value	Acquired demyelinating ds (N = 18)	p-value
α-Synuclein (ng/ml)	8.0 ± 4.3	9.5 ± 5.0	0.0160*	11.2 ± .5.9	0.0250*
IFN-β (pg/ml)	397.5 ± 312.3	475.5 ± 333.8	0.0646	814.9 ± 1227.3	0.4672
IFN-γ (pg/ml)	3.5 ± 9.3	4.6 ± 13.1	0.1718	6.1 ± 18.5	0.5644
IL-1β (pg/ml)	0.5 ± 1.0	3.5 ± 13.9	0.1038	0.4 ± 0.7	0.3141
IL-6 (pg/ml)	0.9 ± 1.4	4.2 ± 11.8	0.0052*	7.0 ± 15.5	0.1833
IL-10 (pg/ml)	4.0 ± 9.9	9.2 ± 20.9	< 0.0001**	17.7 ± 34.9	0.0120*
TNF-α (pg/ml)	10.2 ± 6.3	14.3 ± 14.8	0.0475*	12.1 ± 11.6	0.3959

Data, mean ± standard deviation; CNS, central nervous system; Acquired demyelinating ds, acquired demyelinating disorders of the central nervous system; IFN, interferon; IL, interleukin; TNF, tumor necrosis factor; *p < 0.05, **p < 0.001

ISSN: 1471-2377