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Table 5 Correlations of serum α-synuclein and cytokines with measures of disease severity in epilepsy and acquired demyelinating disorders of CNS

From: Serum α-synuclein and IL-1β are increased and correlated with measures of disease severity in children with epilepsy: potential prognostic biomarkers?

Serum levelsEpilepsy (N = 115)Acquired demyelinating ds (N = 18)
Age of disease onsetDuration of last sz before the blood collectionNumber of AEDDisease durationAge of disease onsetDisease duration
p-valuerp-valuerp-valuerp-valuerp-valuerp-valuer
α-Synuclein (ng/ml)0.6352 0.0438*0.18840.0222*0.21320.5575 0.4864 0.0374*0.5892
IFN-β (pg/ml)0.6274 0.8148 0.6119 0.6568 0.2188 0.3941 
IFN-γ (pg/ml)< 0.0001**−0.41970.4590 0.0235*0.22880.0872 0.8242 0.6411 
IL-1β (pg/ml)0.0110*−0.25450.4913 0.0005**0.34280.1359 0.8999 0.8044 
IL-6 (pg/ml)0.0066*−0.27140.0057*0.27730.7776 0.3343 0.0429*−0.62720.3101 
IL-10 (pg/ml)0.0041*−0.28640.6248 0.3572 0.7683 0.2273 0.4465 
TNF-α (pg/ml)0.4018 0.7054 0.2542 0.6594 0.3781 0.3813 
Exosomal α-synuclein (ng/ml)0.1042 0.1136 0.3488 0.2914 0.5298 0.0571 
  1. CNS, central nervous system; Acquired demyelinating ds, acquired demyelinating disorders of the central nervous system; sz, seizure; AED, antiepileptic drugs; IFN, interferon; IL, interleukin; TNF, tumor necrosis factor; *p < 0.05, **p < 0.001