Serum α-synuclein and IL-1β are increased and correlated with measures of disease severity in children with epilepsy: potential prognostic biomarkers?

Table 5 Correlations of serum α-synuclein and cytokines with measures of disease severity in epilepsy and acquired demyelinating disorders of CNS

Serum levels	Epilepsy (N = 115)								Acquired demyelinating ds (N = 18)
	Age of disease onset		Duration of last sz before the blood collection		Number of AED		Disease duration		Age of disease onset		Disease duration
	p-value	r	p-value	r	p-value	r	p-value	r	p-value	r	p-value	r
α-Synuclein (ng/ml)	0.6352		0.0438*	0.1884	0.0222*	0.2132	0.5575		0.4864		0.0374*	0.5892
IFN-β (pg/ml)	0.6274		0.8148		0.6119		0.6568		0.2188		0.3941
IFN-γ (pg/ml)	< 0.0001**	−0.4197	0.4590		0.0235*	0.2288	0.0872		0.8242		0.6411
IL-1β (pg/ml)	0.0110*	−0.2545	0.4913		0.0005**	0.3428	0.1359		0.8999		0.8044
IL-6 (pg/ml)	0.0066*	−0.2714	0.0057*	0.2773	0.7776		0.3343		0.0429*	−0.6272	0.3101
IL-10 (pg/ml)	0.0041*	−0.2864	0.6248		0.3572		0.7683		0.2273		0.4465
TNF-α (pg/ml)	0.4018		0.7054		0.2542		0.6594		0.3781		0.3813
Exosomal α-synuclein (ng/ml)	0.1042		0.1136		0.3488		0.2914		0.5298		0.0571

CNS, central nervous system; Acquired demyelinating ds, acquired demyelinating disorders of the central nervous system; sz, seizure; AED, antiepileptic drugs; IFN, interferon; IL, interleukin; TNF, tumor necrosis factor; *p < 0.05, **p < 0.001

ISSN: 1471-2377