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Table 3 Comparison of patients with different PLAN-related genotypes

From: Genotype-phenotype correlations of adult-onset PLA2G6-associated Neurodegeneration: case series and literature review

CharacteristicsHomozygous p.D331Y mutations
N = 5
Compound heterozygous p.D331Y/ other mutations
N = 5
Homozygous
Mutations other than p.D331Y
N = 17
Compound Heterozygous
mutations other than p.D331Y
N = 8
P-value
Age at onset, years33.0 ± 4.825.4 ± 6.323.2 ± 11.016.8 ± 9.90.23
Sex, male2 (50.0%)2 (40.0%)6 (35.3%)5 (62.5%)0.41
Ethnicity
 Chinese5 (100.0%)5 (100.0%)01 (12.5%)< 0.001**
 East Asian001 (4.8%)4 (50.0%)0.01*
 South Asian004 (19.0%)00.16
 Middle Eastern0014 (66.7%)0< 0.01**
 Caucasian002 (9.5%)3 (37.5%)0.11
Main clinical subtypes
  Dystonia-parkinsonism03 (60.0%)9 (52.9%)2 (25.0%)0.07
  Early-onset PD5 (100.0%)06 (35.3%)6 (75.0%)0.01*
  HSP01 (20.0%)2 (11.8%)00.78
  Ataxia01 (20.0%)000.68
  1. Data are the number (%) or the mean ± SD. PLAN, Phospholipase A2 group VI-associated neurodegeneration; PD, Parkinson’s disease; HSP, hereditary spastic paraparesis. **P < 0.05; **P < 0.01. P-values that compare individual characteristics between four groups with different genotypes were evaluated with an analysis of variance. Variables without a normal distribution were compared with the Kruskal-Wallis test, the non-parametric equivalent of the independent sample t-test