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Table 5 Summary of findings – tuberculous meningitis

From: Ventriculoperitoneal shunt insertion in human immunodeficiency virus infected adults: a systematic review and meta-analysis

Outcomes

Pooled outcome

№ of participants

(studies)

Quality of the evidence

(GRADE)

Comments

Survival

 Survival follow up: 1 months

34 (51.5%; range 33.3–61.9%)

66 (3 observational studies) [44, 46, 79]

LOW a

 

 Survival follow up: 6 months

9 (42.9%)

21 (1 observational study) [44]

VERY LOW a,b

 

 Survival follow up: 12 months

7 (33.3%)

21 (1 observational study) [44]

VERY LOW a,b

 

AIDS specific mortality

No studies reported AIDS specific mortality at any point

VPS survival

No studies reported VPS failure or survival rates at any time point

 

Operative complication

No studies reported rates of operative complication at any time point

Validated outcome score

  

Glasgow outcome score (GOS)

follow up: 1 month

GOS 1–3: 26 (57.8%)

GOS 4–5: 19 (42.2%)

45 (2 observational studies) [46, 79]

LOW a

GOS 1–3 signifies death to severe disability

GOS 4–5 signifies moderate to low disability

Glasgow outcome score (GOS)

follow up: 6 months

GOS 1–3: 16 (76.2%)

GOS 4–5: 5 (23.8%)

21 (1 observational study) [46]

VERY LOW a,c

GOS 1–3 signifies death to severe disability

GOS 4–5 signifies moderate to low disability

Glasgow outcome score (GOS)

follow up: 12 months

No studies reported a validated outcome score at 12 months

  1. a Possibly selected observational case series level data
  2. b Incomplete long-term follow-up
  3. c Mean follow up 130 days. Range of 3–25 months