Table 1 Baseline characteristics of patients according to eGRF
eGFR (ml/min/1.73 m2) | |||||
|---|---|---|---|---|---|
≤44 (G3b–5) n = 27 | 45–59 (G3a) n = 46 | 60–89 (G2) n = 170 | ≥90 (G1) n = 130 | p | |
Demographic | |||||
Age, y | 82 (75–85) | 77 (66–83.3) | 76 (70–81) | 63.5 (55–70) | < 0.001 |
Male | 16 (59.3) | 30 (65.2) | 102 (60.0) | 87 (66.9) | 0.621 |
Weight, Kg | 64 (60–70) | 65 (60–70) | 65 (60–70) | 65 (60–75) | 0.633 |
Cardiovascular risk factors | |||||
Hypertension | 19 (70.4) | 39 (84.8) | 131 (77.1) | 82 (63.1) | 0.011 |
Diabetes | 8 (29.6) | 10 (21.7) | 32 (18.8) | 24 (18.5) | 0.573 |
Coronary artery disease | 8 (29.6) | 15 (32.6) | 46 (27.1) | 15 (11.5) | 0.002 |
Atrial fibrillation | 14 (51.9) | 19 (41.3) | 69 (40.6) | 26 (20.0) | < 0.001 |
TIA/stroke | 5 (18.5) | 14 (30.4) | 51 (30.2) | 22 (16.9) | 0.04 |
Smokinga | 6 (22.2) | 19 (41.3) | 50 (29.6) | 57 (43.8) | 0.026 |
Clinical features on admission | |||||
NIHSS score | 16 (14–20) | 16.5 (11–24) | 16 (12–20) | 13.5 (9–18) | 0.005 |
OTT, min | 202 (134–345) | 178 (136–309) | 195 (130–333) | 211 (155–379) | 0.352 |
SBP, mmHg | 146 ± 22 | 144 ± 21 | 144 ± 24 | 138 ± 23 | 0.127 |
DBP, mmHg | 88 ± 17 | 86 ± 16 | 87 ± 15 | 83 ± 15 | 0.149 |
Prior tPA | 7 (25.9) | 21 (45.9) | 70 (41.2) | 61 (46.9) | 0.223 |
TOAST classification | |||||
Large artery atherosclerosis | 10 (37) | 18 (39.1) | 70 (41.2) | 72 (55.4) | 0.047 |
Cardioembolism | 16 (59.3) | 25 (54.3) | 87 (51.2) | 46 (35.4) | 0.013 |
Other | 1 (3.7) | 3 (6.5) | 13 (7.6) | 12 (9.2) | 0.875 |
Occlusion site | |||||
Anterior circulation | 23 (85.2) | 38 (82.6) | 138 (82.1) | 102 (79.1) | 0.826 |
ICA/ICA terminal bifurcation | 8 (29.6) | 24 (52.2) | 56 (33.3) | 46 (35.7) | 0.102 |
Middle cerebral artery | 15 (55.6) | 14 (30.4) | 82 (48.8) | 56 (43.4) | 0.099 |
Posterior circulation | 4 (14.8) | 8 (17.4) | 30 (17.9) | 27 (20.9) | 0.848 |
Basilar artery | 4 (14.8) | 5 (10.9) | 14 (8.3) | 16 (12.4) | 0.348 |
Vertebral artery | 0 | 2 (4.3) | 15 (8.9) | 10 (7.8) | 0.404 |
Posterior cerebral artery | 0 | 1 (2.2) | 1 (0.5) | 1 (0.8) | 0.618 |
Laboratory tests | |||||
Platelet count, 10^9/L | 158 (137–232) | 171 (143–220) | 174.5 (141–223) | 189 (144–231) | 0.446 |
PT/INR | 1.04 (0.99–1.10) | 1.02 (0.99–1.07) | 1.01 (0.96–1.08) | 0.99 (0.95–1.06) | 0.034 |
Glucose, mmol/L | 7.0 (5.8–9.4) | 7.0 (5.6–8.2) | 6.5 (5.4–8.0) | 6.2 (5.1–7.5) | 0.027 |
Glycosylated hemoglobin, % | 5.8 (5.7–6.8) | 6.2 (5.6–6.9) | 5.9 (5.5–6.4) | 5.8 (5.5–6.3) | 0.284 |
Total cholesterol, mmol/L | 3.54 (2.98–4.85) | 3.77 (3.32–4.78) | 4.14 (3.51–4.87) | 4.35 (3.59–5.14) | 0.025 |
LDL, mmol/L | 2.21 (1.78–2.85) | 2.29 (1.73–3.07) | 2.43 (1.92–3.06) | 2.70 (2.12–3.24) | 0.037 |
HDL, mmol/L | 1.13 ± 0.33 | 1.13 ± 0.30 | 1.12 ± 0.27 | 1.16 ± 0.31 | 0.667 |
Triglyceride, mmol/L | 0.9 (0.75–1.85) | 1.02 (0.73–1.61) | 1.04 (0.76–1.47) | 1.09 (0.75–1.57) | 0.843 |
Urea nitrogen, mmol/L | 9.64 (7.45–12.10) | 7.50 (5.41–8.95) | 5.93 (4.81–7.21) | 4.70 (4.09–5.54) | < 0.001 |
Homocysteine, umol/L | 14.45 (12.00–17.88) | 14.66 (12.14–18.33) | 13.01 (10.89–16.78) | 11.51 (9.76–13.91) | < 0.001 |