Aneurysmal subarachnoid haemorrhage: effect of CRHR1 genotype on fatigue and depression

BMC Neurology

Table 4 Influence of genotype on EST-Q outcomes (only statistically significant results are reported)

SNP	Allele	Model	OR	95% CI	p	OR*	95% CI*	p*
Depression
Rs110402	Minor	Additive	0.50	0.28–0.92	0.027	0.50	0.26–0.94	0.032
Fatigue
Rs110402	Minor	Additive	0.46	0.26–0.8	0.006	0.48	0.27–0.85	0.012
Rs7209436	Minor	Recessive	0.22	0.07–0.69	0.009	0.23	0.07–0.75	0.015
Rs242924	Minor	Recessive	0.35	0.14–0.9	0.030	0.37	0.14–0.98	0.044
TAT-haplotype	Minor	Additive	0.26	0.08–0.81	0.021	0.27	0.08–0.88	0.030
Insomnia
Rs242939	Minor	Additive	0.43	0.18–1.02	0.057	0.38	0.15–0.96	0.042

Abbreviations: OR odds ratio, CI confidence interval. P-values that are adjusted for gender, Hunt Hess score, patient age and time of evaluation from aSAH are marked with *. P-values that survived the Bonferroni correction are marked with bold

ISSN: 1471-2377