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Table 1 Demographics of the patients with MSA, SCA3, and the controls

From: Vertical pons hyperintensity and hot cross bun sign in cerebellar-type multiple system atrophy and spinocerebellar ataxia type 3

 

Sex Distributiona

(Male/Female)

Age at MRIb

(years, median, range)

Age at Onsetc

(years, mean±SD)

Disease Durationd

(years, median, range)

Frequency of MRIb

(times, median, range)

MSA (n = 80)

40/40

67.0 (46-82)

63.2 ± 8.7

2.2 (0.2-8.3)

1 (1-5)

MSA-C (n = 41)

21/20

63.5 (46-82)

61.3 ± 9.9

2.1 (0.2-8.3)

1 (1-5)

SCA3 (n = 26)

10/16

58.5 (24-82)

46.0 ± 17.2

6.7 (0.8-24.0)

1 (1-6)

Controls (n = 22)

11/11

64.0 (42-82)

NA

NA

1 (1-1)

P value for MSA vs. SCA3

NA

NA

<0.001

<0.001

NA

P value for MSA-C vs. SCA3

NA

NA

<0.001

<0.001

NA

P value for group comparison

(MSA, SCA3, Controls)

0.575

0.01

NA

NA

0.002

P value for group comparison

(MSA-C, SCA3, Controls)

0.568

0.107

NA

NA

0.003

P value for post-hoc group comparisons

 MSA vs. SCA3

NA

0.003

NA

NA

0.597

 MSA vs. Controls

NA

0.235

NA

NA

<0.001

 SCA3 vs. Controls

NA

0.191

NA

NA

0.001

 MSA-C vs. SCA3

NA

NA

NA

NA

0.713

 MSA-C vs. Controls

NA

NA

NA

NA

0.001

  1. aChi-squared test (post-hoc chi-squared tests adjusted for multiple comparison: P < 0.05/3 = 0.0167)
  2. bNonparametric test (Kruskal-Wallis 1-way ANOVA with post-hoc Mann-Whitney U test adjusted for multiple comparison: P < 0.05/3 = 0.0167)
  3. cStudent's t-test
  4. dMann-Whitney U test