Table 1 Demographics and clinical characteristics by MS status
No MS N = 1,054,816 | Prevalent MS N = 3286 | P-value | |
|---|---|---|---|
Mean age, years ± SD | 48.0 ± 18.4 | 50.6 ± 12.9 | < 0.0001 |
Women, n (%) | 633,762 (60.1) | 2552 (77.7) | < 0.0001 |
Race-ethnicity, n (%) | < 0.0001 | ||
Non-Hispanic white | 584,042 (55.4) | 2366 (72.0) | |
Non-Hispanic black | 31,309 (3.0) | 170 (5.2) | |
Non-Hispanic Asian | 136,707 (13.0) | 90 (2.7) | |
Hispanic | 106,661 (10.1) | 201 (6.1) | |
Non-Hispanic Other | 50,642 (4.8) | 154 (4.7) | |
Non-Hispanic Unknown | 145,455 (13.8) | 305 (9.3) | |
Median household income, n (%) | < 0.0001 | ||
< $50 K | 137,779 (13.1) | 479 (14.6) | |
$50 K to <$75 K | 367,212 (34.8) | 1253 (38.1) | |
$75 K to <$100 K | 304,322 (28.9) | 925 (28.1) | |
$100 K to $200 K | 229,054 (21.7) | 581 (17.7) | |
> $200 K | 2388 (0.2) | 5 (0.2) | |
Missing | 14,061 (1.3) | 43 (1.3) | |
Family history of MS, n (%) | 3157 (0.3) | 116 (3.5) | < 0.0001 |
Smoking history, n (%) | |||
Never smoker | 660,752 (62.6) | 1780 (54.2) | < 0.0001 |
Ever smoker | 194,810 (18.5) | 786 (23.9) | |
Current smoker | 77,208 (7.3) | 378 (11.5) | |
Unknown | 122,046 (11.6) | 342 (10.4) | |
CCI score, n (%) | 0.002 | ||
0 | 814,864 (77.3) | 2599 (79.1) | |
1–2 | 220,477 (20.9) | 655 (19.9) | |
3–4 | 17,695 (1.7) | 28 (0.9) | |
5–6 | 1694 (0.2) | 4 (0.1) | |
> 6 | 88 (0.01) | 0 (0) | |
Mean medications, count ± SD | 0.9 ± 1.4 | 1.3 ± 1.9 | < 0.0001 |
Mean BMI, kg/m2 ± SD | 27.4 ± 6.4 | 27.7 ± 6.8 | 0.07 |
Depression, n (%) | 41,785 (4.0) | 321 (9.8) | < 0.0001 |
Type 1 diabetes, n (%) | 4474 (0.4) | 15 (0.5) | 0.78 |
Thyroid disease, n (%) | 48,972 (4.6) | 188 (5.7) | 0.003 |
Digestive diseases, n (%) | 4843 (0.5) | 14 (0.4) | 0.78 |
Ulcerative colitis | 1939 (0.2) | 5 (0.2) | 0.67 |
Gastroenteritis/colitis | 992 (0.1) | 0 (0) | 0.08 |
Crohn’s disease | 1422 (0.1) | 4 (0.1) | 0.84 |
Celiac disease | 585 (0.1) | 4 (0.1) | 0.11 |
Rheumatic disease, n (%) | 7263 (0.7) | 23 (0.7) | 0.94 |
Lupus | 1378 (0.1) | 5 (0.2) | 0.73 |
Rheumatoid arthritis | 5015 (0.5) | 11 (0.3) | 0.24 |
Sjogren’s syndrome | 649 (0.1) | 6 (0.2) | 0.02 |
Systemic sclerosis | 278 (0.03) | 1 (0.03) | 0.58 |
Polymyositis | 118 (0.01) | 0 (0) | 1.0 |
Dermatomyositis | 118 (0.01) | 0 (0) | 1.0 |