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Table 1 Demographics and clinical characteristics by MS status

From: Multiple sclerosis in a multi-ethnic population from Northern California: a retrospective analysis, 2010–2016

 No MS
N = 1,054,816
Prevalent MS
N = 3286
P-value
Mean age, years ± SD48.0 ± 18.450.6 ± 12.9< 0.0001
Women, n (%)633,762 (60.1)2552 (77.7)< 0.0001
Race-ethnicity, n (%)< 0.0001
 Non-Hispanic white584,042 (55.4)2366 (72.0) 
 Non-Hispanic black31,309 (3.0)170 (5.2) 
 Non-Hispanic Asian136,707 (13.0)90 (2.7) 
 Hispanic106,661 (10.1)201 (6.1) 
 Non-Hispanic Other50,642 (4.8)154 (4.7) 
 Non-Hispanic Unknown145,455 (13.8)305 (9.3) 
Median household income, n (%)< 0.0001
  < $50 K137,779 (13.1)479 (14.6) 
 $50 K to <$75 K367,212 (34.8)1253 (38.1) 
 $75 K to <$100 K304,322 (28.9)925 (28.1) 
 $100 K to $200 K229,054 (21.7)581 (17.7) 
  > $200 K2388 (0.2)5 (0.2) 
 Missing14,061 (1.3)43 (1.3) 
Family history of MS, n (%)3157 (0.3)116 (3.5)< 0.0001
Smoking history, n (%)
 Never smoker660,752 (62.6)1780 (54.2)< 0.0001
 Ever smoker194,810 (18.5)786 (23.9) 
 Current smoker77,208 (7.3)378 (11.5) 
 Unknown122,046 (11.6)342 (10.4) 
CCI score, n (%)0.002
 0814,864 (77.3)2599 (79.1) 
 1–2220,477 (20.9)655 (19.9) 
 3–417,695 (1.7)28 (0.9) 
 5–61694 (0.2)4 (0.1) 
  > 688 (0.01)0 (0) 
Mean medications, count ± SD0.9 ± 1.41.3 ± 1.9< 0.0001
Mean BMI, kg/m2 ± SD27.4 ± 6.427.7 ± 6.80.07
Depression, n (%)41,785 (4.0)321 (9.8)< 0.0001
Type 1 diabetes, n (%)4474 (0.4)15 (0.5)0.78
Thyroid disease, n (%)48,972 (4.6)188 (5.7)0.003
Digestive diseases, n (%)4843 (0.5)14 (0.4)0.78
Ulcerative colitis1939 (0.2)5 (0.2)0.67
Gastroenteritis/colitis992 (0.1)0 (0)0.08
Crohn’s disease1422 (0.1)4 (0.1)0.84
Celiac disease585 (0.1)4 (0.1)0.11
Rheumatic disease, n (%)7263 (0.7)23 (0.7)0.94
Lupus1378 (0.1)5 (0.2)0.73
Rheumatoid arthritis5015 (0.5)11 (0.3)0.24
Sjogren’s syndrome649 (0.1)6 (0.2)0.02
Systemic sclerosis278 (0.03)1 (0.03)0.58
Polymyositis118 (0.01)0 (0)1.0
Dermatomyositis118 (0.01)0 (0)1.0
  1. BMI body mass index, CCI Charlson comorbidity index, MS multiple sclerosis, SD standard definition