No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - a seven-year follow-up study

Table 1 Baseline characteristics (n = 208) and assessments in survivors at 7 years (n = 111)

	Baseline	7-year follow-up
Male (%) Mean age, years (SD) Less than 9 years of education (%)	105 (51) 72.0 (12.2) 50 (24)	46 (41) 75.2 (11.2)
Stroke subtype (%)
Cerebral infarction TIA Cerebral hemorrhage	164 (79) 28 (14) 16 (7)
Risk factors (%)
Hypertension* Hyperlipidemia Diabetes Cigarette smoking (present) Coronary heart disease Atrial fibrillation Daily alcohol use BMI > 25	123 (59) 117 (56) 23 (11) 18 (18) 45 (22) 65 (31) 20 (24) 119 (57)
TOAST classification (%)
Large-vessel disease Cardio-embolic disease Small-vessel disease Stroke of undetermined etiology	21 (10) 60 (29) 64 (31) 63 (30)
Assessments. Mean (SD) (n)
IQCODE MMSE NIHSS BI mRS TMT-A TMT-B 10-Word test immediate recall 10-Word test, delayed recall	3.1 (0.2) (n = 208)
	26.0 (4.5) (n = 195) 2.44 (4.6) (n = 208) 17.5 (5.1) (n = 208) 1.5 (1.4) (n = 208) 73.7 (66.7) (n = 177) 152.8 (89.8) (n = 152) 17.9 (2.9) (n = 170) 4.3 (2.5) (n = 184)	25.8 (5.9) (n = 109) 1.02 (2.3) (109) 18.7 (3.7) (109) 1.4 (1.3) (109) 55.7 (39.6) (n = 101) 126.4 (67.7) (n = 82) 22.5 (8) (n = 106) 4.7 (3) (n = 105)

TIA = Transistent Ischemic Attack; Hyperlipidemia = total cholesterol > 5 mmol/L or LDL > 3 mmol/L; LDL = Low Density Lipoprotein; Diabetes = an established diagnosis or Haemoglobin A1C (HbA1c) ≥7.0; Coronary Heart Disease = previous myocardial infarction or present angina pectoris; BMI=Body mass index; TOAST = the trial of org 10,172 in acute stroke treatment classification; NIHSS=National Institute of Health Stroke Scale; BI=Barthel Activities of Daily Living Index; mRS = modified Rankin scale; IQCODE = the informant questionnaire on cognitive decline in the elderly. MMSE = Mini Mental State Examination; SD = standard deviation.* Hypertension = use of BP lowering drugs at baseline

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