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Table 2 Characteristics at baseline, clinical cognitive profile and MRI findings at 1 year in stroke survivors by PET or no PET at 7 years

From: No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - a seven-year follow-up study

 

PET

NO PET

P value

N

26

85

 

Male (%)

18 (69)

43 (51)

0.227

Mean age, years (SD)

72.9 (7.0)

75.9 (11.8)

0.239

Less than 9 years of education (%)

4 (15)

18 (21)

0.776

Living alone (%)

4 (15)

24 (28)

0.288

Stroke subtype (%)

  

0.926

 Cerebral infarction

20 (77)

66 (78)

 

 TIA

4 (15)

11 (13)

 

 Cerebral hemorrhage

2 (8)

8 (9)

 

TOAST classification (%)

  

0.724

 Large-vessel disease

2 (8)

12 (14)

 

 Cardio-embolic disease

8 (31)

19 (22)

 

 Small-vessel disease

9 (35)

29 (34)

 

 Stroke of undetermined etiology

7 (27)

25 (30)

 

Assessments. Mean (SD) (n)

 NIHSS

1.12 (2.1) (26)

1.99 (3.6) (85)

0.247

 mRS

1.0 (1.2) (26)

1.26 (1.2) (85)

0.266

 IQCODE

3.0 (0.1) (26)

3.1 (0.2) (85)

0.641

 MMSE

27.8 (2.1) (26)

26.5 (4.0) (82)

0.113

Clinical profile 12 months

 Dementia

1 (26)

13 (84)

0.223

 MCI

6 (26)

31 (84)

0.286

 Normal cognition

19 (26)

40 (84)

0.040

MRI 12 months. Mean (SD) (n)

 MTLA grade

0.79 (0.8) (24)

1.18 (1.2) (77)

0.135

 Fazekas score

1.52 (0.8) (25)

1.86 (0.9) (76)

0.095

 Global Cortical Atrophy

1.28 (0.7) (25)

1.48 (0.6) (75)

0.177

 CSF (Aβ)-42 (ng/L) 12 months (n)

840 (250) (13)

861 (302) (41)

0.824

 CSF total tau (ng/L) 12 months (n)

270 (101) (13)

387 (192) (41)

0.040

  1. TIA = Transient Ischemic Attack; TOAST = the trial of org 10,172 in acute stroke treatment classification; NIHSS=National Institute of Health Stroke Scale; BI=Barthel Activities of Daily Living Index; mRS = modified Rankin scale; IQCODE = the informant questionnaire on cognitive decline in the elderly; MMSE = Mini Mental State Examination; SD = standard deviation;MCI = mild cognitive impairment; MTLA = medial temporal lobe atrophy. CSF (Aβ)-42 = cerebrospinal fluid amyloid-β peptide