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Table 2 Characteristics at baseline, clinical cognitive profile and MRI findings at 1 year in stroke survivors by PET or no PET at 7 years

From: No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - a seven-year follow-up study

 PETNO PETP value
N2685 
Male (%)18 (69)43 (51)0.227
Mean age, years (SD)72.9 (7.0)75.9 (11.8)0.239
Less than 9 years of education (%)4 (15)18 (21)0.776
Living alone (%)4 (15)24 (28)0.288
Stroke subtype (%)  0.926
 Cerebral infarction20 (77)66 (78) 
 TIA4 (15)11 (13) 
 Cerebral hemorrhage2 (8)8 (9) 
TOAST classification (%)  0.724
 Large-vessel disease2 (8)12 (14) 
 Cardio-embolic disease8 (31)19 (22) 
 Small-vessel disease9 (35)29 (34) 
 Stroke of undetermined etiology7 (27)25 (30) 
Assessments. Mean (SD) (n)
 NIHSS1.12 (2.1) (26)1.99 (3.6) (85)0.247
 mRS1.0 (1.2) (26)1.26 (1.2) (85)0.266
 IQCODE3.0 (0.1) (26)3.1 (0.2) (85)0.641
 MMSE27.8 (2.1) (26)26.5 (4.0) (82)0.113
Clinical profile 12 months
 Dementia1 (26)13 (84)0.223
 MCI6 (26)31 (84)0.286
 Normal cognition19 (26)40 (84)0.040
MRI 12 months. Mean (SD) (n)
 MTLA grade0.79 (0.8) (24)1.18 (1.2) (77)0.135
 Fazekas score1.52 (0.8) (25)1.86 (0.9) (76)0.095
 Global Cortical Atrophy1.28 (0.7) (25)1.48 (0.6) (75)0.177
 CSF (Aβ)-42 (ng/L) 12 months (n)840 (250) (13)861 (302) (41)0.824
 CSF total tau (ng/L) 12 months (n)270 (101) (13)387 (192) (41)0.040
  1. TIA = Transient Ischemic Attack; TOAST = the trial of org 10,172 in acute stroke treatment classification; NIHSS=National Institute of Health Stroke Scale; BI=Barthel Activities of Daily Living Index; mRS = modified Rankin scale; IQCODE = the informant questionnaire on cognitive decline in the elderly; MMSE = Mini Mental State Examination; SD = standard deviation;MCI = mild cognitive impairment; MTLA = medial temporal lobe atrophy. CSF (Aβ)-42 = cerebrospinal fluid amyloid-β peptide