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Table 2 Characteristics at baseline, clinical cognitive profile and MRI findings at 1 year in stroke survivors by PET or no PET at 7 years

From: No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - a seven-year follow-up study

  PET NO PET P value
N 26 85  
Male (%) 18 (69) 43 (51) 0.227
Mean age, years (SD) 72.9 (7.0) 75.9 (11.8) 0.239
Less than 9 years of education (%) 4 (15) 18 (21) 0.776
Living alone (%) 4 (15) 24 (28) 0.288
Stroke subtype (%)    0.926
 Cerebral infarction 20 (77) 66 (78)  
 TIA 4 (15) 11 (13)  
 Cerebral hemorrhage 2 (8) 8 (9)  
TOAST classification (%)    0.724
 Large-vessel disease 2 (8) 12 (14)  
 Cardio-embolic disease 8 (31) 19 (22)  
 Small-vessel disease 9 (35) 29 (34)  
 Stroke of undetermined etiology 7 (27) 25 (30)  
Assessments. Mean (SD) (n)
 NIHSS 1.12 (2.1) (26) 1.99 (3.6) (85) 0.247
 mRS 1.0 (1.2) (26) 1.26 (1.2) (85) 0.266
 IQCODE 3.0 (0.1) (26) 3.1 (0.2) (85) 0.641
 MMSE 27.8 (2.1) (26) 26.5 (4.0) (82) 0.113
Clinical profile 12 months
 Dementia 1 (26) 13 (84) 0.223
 MCI 6 (26) 31 (84) 0.286
 Normal cognition 19 (26) 40 (84) 0.040
MRI 12 months. Mean (SD) (n)
 MTLA grade 0.79 (0.8) (24) 1.18 (1.2) (77) 0.135
 Fazekas score 1.52 (0.8) (25) 1.86 (0.9) (76) 0.095
 Global Cortical Atrophy 1.28 (0.7) (25) 1.48 (0.6) (75) 0.177
 CSF (Aβ)-42 (ng/L) 12 months (n) 840 (250) (13) 861 (302) (41) 0.824
 CSF total tau (ng/L) 12 months (n) 270 (101) (13) 387 (192) (41) 0.040
  1. TIA = Transient Ischemic Attack; TOAST = the trial of org 10,172 in acute stroke treatment classification; NIHSS=National Institute of Health Stroke Scale; BI=Barthel Activities of Daily Living Index; mRS = modified Rankin scale; IQCODE = the informant questionnaire on cognitive decline in the elderly; MMSE = Mini Mental State Examination; SD = standard deviation;MCI = mild cognitive impairment; MTLA = medial temporal lobe atrophy. CSF (Aβ)-42 = cerebrospinal fluid amyloid-β peptide