Skip to main content

Table 2 Averaged hemodynamic and metabolic parameters during the study period in the overall population

From: Salt wasting syndrome in brain trauma patients: a pathophysiologic approach using sodium balance and urinary biochemical analysis

 Study periodDay 1–2Day 3–4Day 5–7
Natremia (mmol/L)142 [139–144]142 [140–146]143 [140–147]140 [138–143] *,
Hyponatremia (Na ≤ 135 mmol/)16 (27)0 (0)5 (8)11 (18) *
Fluid intake (L/24 h)3.2 [2.8–3.6]3.3 [2.9–3.8]3.2 [2.7–3.7]3.2 [2.5–3.7] *
Diuresis (L/24 h)2.2 [1.9–2.8]1.8 [1.3–2.5]2.2 [1.6–2.9]2.4 [1.8–2.9] *
Fluid balance (L/24 h)0.8 [0.6–1.2]1.4 [0.4–2.0]1.0 [0.4–1.4]0.6 [− 0.1–1.1] *
Sodium intake (mmol/24 h)323 [277–378]363 [299–432]295 [234–371]302 [229–365] *
Urinary sodium excretion (mmol/24 h)284 [221–362]132 [91–275]309 [187–422]310 [226–409] *
Sodium balance (mmol/24 h)47 [− 33–104]215 [84–293]16 [− 115–106]22 [− 85–90] *
24-h CLCR(ml/min/1.73m2)143 [116–160]136 [96–154]143 [110–165]147 [115–166] *
Augmented renal clearance32 (53)33 (55)34 (57)33 (55)
Urinary osmolality (mmol/L)569 [503–653]498 [423–627]590 [487–655]603 [510–700] *
24-h CLH2O(ml/min/1.73m2)−1.3 [− 1.5 – − 1.0]− 0.8 [− 1.2 – − 0.4]− 1.3 [− 1.6 – − 0.8]− 1.6 [− 2.1 – − 1.1] *,
Fractional excretion of sodium (%)0.94 [0.76–1.21]0.56 [0.33–1.15]0.98 [0.70–1.40]0.94 [0.72–1.31] *
Fractional excretion of urate (%)19 [12–22]13 [11–18]16 [12–21]22 [13–28] *,
Mean MAP92 [87–96]87 [83–92]91 [85–97]93 [88–100] *
Use of vasopressor54 (90)54 (90)42 (70)30 (50) *
  1. Data expressed as median [interquartile 25–75] and numbers (percentages)
  2. * = p < 0.05 between period 1 and period 3; † = p < 0.05 between period 2 and period 3 (continuous variables compared using Wilcoxon test for paired samples)