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Table 3 Evolution of hemodynamic and metabolic parameters in patients who presented a first episode of hyponatremia over the study period (N = 16)

From: Salt wasting syndrome in brain trauma patients: a pathophysiologic approach using sodium balance and urinary biochemical analysis

 Day of hyponatremiaDay - 1Day - 2
Natremia (mmol/L)135 [134–135]138 [137–139]141 [139–144] *,
Fluid intake (L/24 h)3.0 [2.5–3.3]2.5 [2.3–3.0]2.7 [2.6–3.0]
Diuresis (L/24 h)2.2 [2.0–3.1]2.3 [1.7–3.2]2.2 [1.9–2.6]
Fluid balance (L/24 h)0.6 [− 0.1–1.0]0.5 [− 0.8–0.9]0.4 [−0.2–1.0]
Sodium intake (mmol/24 h)356 [297–425]278 [224–363]288 [252–319] *
Urinary sodium excretion (mmol/24 h)316 [178–452]372 [288–553]403 [297–466]
Sodium balance (mmol/24 h)87 [− 97–148]− 98 [− 211–74]−130 [− 213 – − 2]
24-h CLCR(ml/min/1.73m2)145 [127–165]161 [139–173]141 [128–163]
Urinary osmolality (mmol/L)595 [491–686]551 [498–712]636 [483–740]
24-h CLH2O(ml/min/1.73m2)- 1.6 [−1.9 – − 1.3]- 1.6 [− 1.9 – − 1.3]- 1.8 [− 2.0 – − 1.1]
Fractional excretion of sodium (%)1.04 [0.52–1.80]0.95 [0.81–2.27]1.15 [0.99–1.63]
Fractional excretion of urate (%)27 [15–28]21 [14–27]23 [16–25] *
BUN (mmol/L)4.9 [3.3–6.3]4.1 [2.5–5.2]3.0 [2.3–4.6] *
Protidemia (g/L)65 [60–67]62 [58–68]58 [53–63] *,
Hte (%)32 [29–36]33 [30–35]31 [30–35]
Mean MAP (mmHg)92 [86–98]94 [91–94]91 [87–94]
Use of vasopressor5 (31)8 (50)8 (50)
  1. Data expressed as median [interquartile 25–75] and numbers (percentages)
  2. * = p < 0.05 between Day − 2 and Day 0; † = p < 0.05 between Day − 2 and Day − 1 (continuous variables compared using Wilcoxon test for paired samples)