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Table 2 Summary statistics for baseline, follow-up, and repeatability measurements

From: Longitudinal functional and imaging outcome measures in FKRP limb-girdle muscular dystrophy

 

Baseline

16- week follow-up (Day 1)

16-week follow-up (Day 2 – repeatability testing)

Summary statistics

Summary statistics

Difference from baseline

Summary statistics

Difference from Day 1

Outcome

Median

IQR

Range

Median

IQR

Range

p-value

95% CI

Median

IQR

Range

p-value

95% CI

Two minute walk distance (2MWD), meters

135

130–163

17–233

141

127–163

14–239

0.984

−3.31-5

145

129–168

18–236

0.082

−2.47-4.82

Ten meter walk/run (10MWR), seconds

7.1

6.3–7.6

2.8–40.4

6.8

6.3–8

2.9–74

0.629

−0.2-0.29

7.3

6.5–8

2.8–58

0.269

−0.1–0

Four-stair climb (4SC), seconds

4.9

3.9–6.6

1.7–49.8

5.1

4.2–7.2

1.9–54.2

0.016

0.1–0.7

5.8

4.5–8.2

1.9–61

0.475

−0.35-0.58

Timed up-and-go (TUG), seconds

10

9–12

6–80

11

9–12

7–81

0.103

0–1

11

9–13

6–90

0.716

−0.82-0.82

Performance of upper limb (PUL)

42

37–42

30–42

42

37–42

29–42

0.553

−1-0

41.5

35–42

29–42

0.567

0–0

Manual muscle sum score (MMT)

182

167–198

145–262

186

175–200

142–258

0.158

−3-13

     

Forced vital capacity (FVC), liters

2.905

2.45–3.71

1.98–5.94

2.97

2.53–3.57

1.96–5.76

0.647

−0.13-0.12

     

Forced expiratory volume (FEV1), liters

2.535

2.26–2.97

1.53–4.72

2.56

1.88–2.94

1.55–4.69

0.053

−0.17-.004

     

Mean inspiratory pressure (MIP), cmH2O

48.5

39–62

26–124

55

43–72

23–117

0.037

0.02–7.98

     

Mean expiratory pressure (MEP), cmH2O

59.5

49–80

31–154

70

52–90

29–128

0.129

−3.96-13.97

     

DEXA - lean body mass, kg

35.3

29.2–38.9

22.7–50.5

34.7

29.8–39

22.1–51.4

0.856

−0.46-0.73

     

DEXA - body fat, kg

29.7

27.9–38.2

15.7–45.8

29.2

28.2–37

16.3–49.2

0.809

−1.03-0.83

     

MRI - intramuscular fat fraction, %

67.9

57.8–72.9

36.2–90.3

69.3

62.4–72.8

38.1–88.5

0.266

−.072–1.86