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Table 2 Summary statistics for baseline, follow-up, and repeatability measurements

From: Longitudinal functional and imaging outcome measures in FKRP limb-girdle muscular dystrophy

  Baseline 16- week follow-up (Day 1) 16-week follow-up (Day 2 – repeatability testing)
Summary statistics Summary statistics Difference from baseline Summary statistics Difference from Day 1
Outcome Median IQR Range Median IQR Range p-value 95% CI Median IQR Range p-value 95% CI
Two minute walk distance (2MWD), meters 135 130–163 17–233 141 127–163 14–239 0.984 −3.31-5 145 129–168 18–236 0.082 −2.47-4.82
Ten meter walk/run (10MWR), seconds 7.1 6.3–7.6 2.8–40.4 6.8 6.3–8 2.9–74 0.629 −0.2-0.29 7.3 6.5–8 2.8–58 0.269 −0.1–0
Four-stair climb (4SC), seconds 4.9 3.9–6.6 1.7–49.8 5.1 4.2–7.2 1.9–54.2 0.016 0.1–0.7 5.8 4.5–8.2 1.9–61 0.475 −0.35-0.58
Timed up-and-go (TUG), seconds 10 9–12 6–80 11 9–12 7–81 0.103 0–1 11 9–13 6–90 0.716 −0.82-0.82
Performance of upper limb (PUL) 42 37–42 30–42 42 37–42 29–42 0.553 −1-0 41.5 35–42 29–42 0.567 0–0
Manual muscle sum score (MMT) 182 167–198 145–262 186 175–200 142–258 0.158 −3-13      
Forced vital capacity (FVC), liters 2.905 2.45–3.71 1.98–5.94 2.97 2.53–3.57 1.96–5.76 0.647 −0.13-0.12      
Forced expiratory volume (FEV1), liters 2.535 2.26–2.97 1.53–4.72 2.56 1.88–2.94 1.55–4.69 0.053 −0.17-.004      
Mean inspiratory pressure (MIP), cmH2O 48.5 39–62 26–124 55 43–72 23–117 0.037 0.02–7.98      
Mean expiratory pressure (MEP), cmH2O 59.5 49–80 31–154 70 52–90 29–128 0.129 −3.96-13.97      
DEXA - lean body mass, kg 35.3 29.2–38.9 22.7–50.5 34.7 29.8–39 22.1–51.4 0.856 −0.46-0.73      
DEXA - body fat, kg 29.7 27.9–38.2 15.7–45.8 29.2 28.2–37 16.3–49.2 0.809 −1.03-0.83      
MRI - intramuscular fat fraction, % 67.9 57.8–72.9 36.2–90.3 69.3 62.4–72.8 38.1–88.5 0.266 −.072–1.86