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Table 3 Multivariate logistic regression models to examine the effect of cytomegalovirus diseases on the development of moderate-to-severe dementia according to sex and age distribution

From: Association between cytomegalovirus end-organ diseases and moderate-to-severe dementia: a population-based cohort study

Type of dementiaSubgroupsCMV diseasesNumber of participantsEventsIRaOR (95% CI)P-value
Model 1Model 2Model 3
AllSexMNo1950425.201 (Ref.)1 (Ref.)1 (Ref.)0.648
Yes3901711.452.19 (1.25–3.85)2.26 (1.27–3.99)2.02 (1.09–3.59)
FNo14856310.501 (Ref.)1 (Ref.)1 (Ref.)
Yes2972119.461.86 (1.13–3.04)1.91 (1.09–3.12)1.93 (1.14–3.23)
Age40–59No203030.351 (Ref.)1 (Ref.)1 (Ref.)0.025
Yes40674.2812.31 (3.18–47.60)12.47 (3.14–48.76)11.68 (2.45–49.37)
60–79No12606212.471 (Ref.)1 (Ref.)1 (Ref.)
Yes2522124.481.97 (1.20–3.24)2.00 (1.21–3.34)1.83 (1.07–3.15)
≥ 80No1454086.741 (Ref.)1 (Ref.)1 (Ref.)
Yes2910145.711.62 (0.81–3.24)1.38 (0.69–2.88)1.31 (0.49–2.83)
ADSexMNo1950293.591 (Ref.)1 (Ref.)1 (Ref.)0.197
Yes390138.762.44 (1.27–4.69)2.47 (1.25–4.72)2.37 (1.21–4.62)
FNo1485488.001 (Ref.)1 (Ref.)1 (Ref.)
Yes297109.271.17 (0.59–2.31)1.22 (0.60–2.45)1.28 (0.61–2.59)
Age40–59No203020.231 (Ref.)1 (Ref.)1 (Ref.)0.037
Yes40642.4410.57 (1.94–57.69)10.62 (1.88–58.76)13.59 (2.14–86.26)
60–79No1260469.251 (Ref.)1 (Ref.)1 (Ref.)
Yes2521416.321.80 (0.99–3.27)1.89 (1.01–3.45)1.77 (0.99–3.30)
≥ 80No1452962.891 (Ref.)1 (Ref.)1 (Ref.)
Yes29572.851.14 (0.44–2.96)1.02 (0.36–2.70)1.01 (0.33–2.76)
VaDSexMNo195070.871 (Ref.)1 (Ref.)1 (Ref.)0.243
Yes39021.351.52 (0.32–7.32)1.58 (0.29–7.90)1.27 (0.19–6.54)
FNo148550.831 (Ref.)1 (Ref.)1 (Ref.)
Yes29754.635.47 (1.58–18.88)5.42 (1.47–17.87)4.31 (1.08–16.51)
Age40–59No203010.121 (Ref.)1 (Ref.)1 (Ref.)0.781
Yes40610.615.21 (0.33–83.36)5.24 (0.28–78.93)1.18 (0.05–23.31)
60–79No126071.411 (Ref.)1 (Ref.)1 (Ref.)
Yes25233.502.40 (0.62–9.26)2.44 (0.60–9.52)1.83 (0.36–7.69)
≥ 80No14548.671 (Ref.)1 (Ref.)1 (Ref.)
Yes29343.714.66 (1.04–20.90)4.34 (0.82–17.59)5.29 (0.78–31.74)
OthersSexMNo195060.741 (Ref.)1 (Ref.)1 (Ref.)0.642
Yes39021.351.80 (0.36–8.92)1.82 (0.23–9.43)1.56 (0.21–7.96)
FNo1485101.671 (Ref.)1 (Ref.)1 (Ref.)
Yes29765.563.28 (1.19–9.03)3.15 (1.07–8.77)3.15 (1.05–9.23)
Age40–59No203000.0
Yes40621.22
60–79No126091.811 (Ref.)1 (Ref.)1 (Ref.)
Yes25244.662.52 (0.77–8.17)2.37 (0.65–8.37)2.41 (0.68–8.29)
≥ 80No145715.181 (Ref.)1 (Ref.)1 (Ref.)
Yes29229.141.74 (0.36–8.41)1.19 (0.20–6.21)1.31 (0.23–7.03)
  1. Data are expressed as number or OR (95% CI). Events indicate the new-onset moderate-to-severe dementia. Model 1, non-adjusted; Model 2, age-, sex-, low income status, and BMI-adjusted; Model 3, age-, sex-, low income status-, BMI-, SOT recipients-, HSCT recipients-, malignant neoplasms-, ESRD on dialysis-, NIDDM-, hypertension-, and dyslipidaemia-adjusted
  2. Abbreviations; AD Alzheimer’s disease, BMI body mass index, CI confidence interval, CMV cytomegalovirus, ESRD end-stage renal disease, F female, HSCT haematopoietic stem cell transplantation, IR incidence rate, M male, No number of patients, NIDDM non-insulin-dependent diabetes mellitus, OR odds ratio, Ref. reference, SOT solid organ transplantation; VaD vascular dementia
  3. aPer 1000 person-years