Extrastriatal 123I-FP-CIT SPECT impairment in Parkinson’s disease – the PPMI cohort

BMC Neurology

Table 3 Correlations between clinical motor and non-motor scales and regional 123I-FP-CIT uptake in PD

Score	Region of interest	Coefficient	pval	95% Confidence Interval
MDS-UPDRS III	PUT*	−9.2	0.022	[− 17; − 1.4]
	CN*	−4.4	0.44	[− 15.6; 6.8]
	PAL*	−1.46	0.67	[−8.1; 5.2]
	INS	− 3.4	0.22	[−8.9; 2.0]
	AMYG	−1.8	0.25	[−4.8; 1.2]
MOCA	PUT	−0.47	0.62	[−2.3; 1.4]
	CN	−0.26	0.74	[−1.8; 1.3]
	PAL	−0.1	0.85	[−1.2; 1]
	INS	−0.02	0.97	[−1.3; 1.2]
	AMYG	−0.26	0.46	[−1; 0.4]
GDS	PUT	0.54	0.39	[−0.7; 1.8]
	CN	−0.30	0.56	[−1.3; 0.7]
	PAL	−0.65	0.08	[−1.4; 0.1]
	INS	0.51	0.22	[−0.3; 1.3]
	AMYG	−0.13	0.59	[−0.6; 1.3]
SCOPA-GI	PUT	−2.2	0.01	[−3.9; −0.5]
	CN	−1.48	0.034	[−2.9; −0.1]
	PAL	−0.06	0.90	[−1.1; 1]
	INS	−0.66	0.25	[−1.8; 0.5]
	AMYG	−0.2	0.54	[−0.8; 0.4]
SCOPA-URO	PUT	−2.7	0.013	[−4.6; −0.6]
	CN	−2.7	0.002	[−4.3; −1.0]
	PAL	−1.4	0.025	[−2.7; −0.2]
	INS	−0.66	0.36	[−2.1; 0.75]
	AMYG	−0.44	0.27	[−1.2; 0.4]
ESS	PUT	−0.79	0.63	[−4; 2.4]
	CN	−0.33	0.81	[−3.1; 2.4]
	PAL	−0.99	0.30	[−2.9; 0.9]
	INS	0.25	0.81	[−1.8; 2.3]
	AMYG	0.01	0.99	[−1.1; 1.1]
RBDSQ	PUT	−3.27	0.010	[−5.7; −0.8]
	CN	−2.35	0.028	[−4.4; − 0.3]
	PAL	−1.56	0.036	[−3.0; −0.1]
	INS	−0.08	0.92	[−1.7; 1.54]
	AMYG	0.37	0.40	[−0.52; 1.27]

Correlations between clinical scores and ¹²³I-FP-CIT ROIs uptake. All uptake values are average (mean of left and right), except * = contralateral side to clinically more affected side. PUT putamen, CN caudate nucleus, PAL pallidum, INS insula, AMYG amygdala. Significant results are highlighted in bold

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