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Table 3 Correlations between clinical motor and non-motor scales and regional 123I-FP-CIT uptake in PD

From: Extrastriatal 123I-FP-CIT SPECT impairment in Parkinson’s disease – the PPMI cohort

Score Region of interest Coefficient pval 95% Confidence Interval
MDS-UPDRS III PUT* −9.2 0.022 [− 17; − 1.4]
CN* −4.4 0.44 [− 15.6; 6.8]
PAL* −1.46 0.67 [−8.1; 5.2]
INS − 3.4 0.22 [−8.9; 2.0]
AMYG −1.8 0.25 [−4.8; 1.2]
MOCA PUT −0.47 0.62 [−2.3; 1.4]
CN −0.26 0.74 [−1.8; 1.3]
PAL −0.1 0.85 [−1.2; 1]
INS −0.02 0.97 [−1.3; 1.2]
AMYG −0.26 0.46 [−1; 0.4]
GDS PUT 0.54 0.39 [−0.7; 1.8]
CN −0.30 0.56 [−1.3; 0.7]
PAL −0.65 0.08 [−1.4; 0.1]
INS 0.51 0.22 [−0.3; 1.3]
AMYG −0.13 0.59 [−0.6; 1.3]
SCOPA-GI PUT −2.2 0.01 [−3.9; −0.5]
CN −1.48 0.034 [−2.9; −0.1]
PAL −0.06 0.90 [−1.1; 1]
INS −0.66 0.25 [−1.8; 0.5]
AMYG −0.2 0.54 [−0.8; 0.4]
SCOPA-URO PUT −2.7 0.013 [−4.6; −0.6]
CN −2.7 0.002 [−4.3; −1.0]
PAL −1.4 0.025 [−2.7; −0.2]
INS −0.66 0.36 [−2.1; 0.75]
AMYG −0.44 0.27 [−1.2; 0.4]
ESS PUT −0.79 0.63 [−4; 2.4]
CN −0.33 0.81 [−3.1; 2.4]
PAL −0.99 0.30 [−2.9; 0.9]
INS 0.25 0.81 [−1.8; 2.3]
AMYG 0.01 0.99 [−1.1; 1.1]
RBDSQ PUT −3.27 0.010 [−5.7; −0.8]
CN −2.35 0.028 [−4.4; − 0.3]
PAL −1.56 0.036 [−3.0; −0.1]
INS −0.08 0.92 [−1.7; 1.54]
AMYG 0.37 0.40 [−0.52; 1.27]
  1. Correlations between clinical scores and 123I-FP-CIT ROIs uptake. All uptake values are average (mean of left and right), except * = contralateral side to clinically more affected side. PUT putamen, CN caudate nucleus, PAL pallidum, INS insula, AMYG amygdala. Significant results are highlighted in bold