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Table 3 Main results of pooled ORs in meta-analysis of MMP family gene polymorphism

From: Matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of multiple sclerosis: systematic review and meta-analysis

Subgroup

 

Sample size

Test of association

Test of heterogeneity

Test of publication bias (Begg’s test)

Test of publication bias (Egger’s test)

Genetic model

Case/Control

OR

95%CI(P-value)

I2 (%)

P

Z

P

T

P

MMP9

Overall

Dominant

1754 / 1702

1.62

1.03– 2.53 (0.03)

85.5

≤0.001

0.80

0.42

1.27

0.24

Recessive

1754 / 1702

2.69

1.68 – 4.29 (≤0.001)

27

0.20

-1.46

0.14

-2.17

0.06

Allelic

1754 / 1702

1.51

1- 2.28 (0.04)

87.8

≤0.001

0.27

0.78

0.34

0.74

TT vs. CC

1754 / 1702

3.20

1.87 – 5.46 (≤0.001)

50

0.04

-1.04

0.29

-1.90

0.9

CT vs.CC

1754 / 1702

1.53

1.02 – 2.28 (0.04)

80.8

≤0.001

0.98

0.32

1

0.34

MMP3

 

Dominant

305/342

1.18

0.66-2.13 (0.57)

0

0.57

-1

0.31

*

*

Recessive

305/342

0.57

0.18-1.79 (0.33)

88.5

≤0.001

1

0.31

*

*

Allelic

305/342

1.11

0.88-1.41 (0.39)

0

0.91

1

0.31

*

*

6A6A vs. 5A5A

305/342

1.15

0.62- 2.11 (0.43)

0

0.48

-1

0.31

*

*

5A6A vs.5A5A

305/342

1.24

0.64 – 2.39 (0.52)

0

0.54

1

0.31

*

*

MMP2

Overall

Dominant

368 /552

1.36

0.39 – 4.78 (0.07)

90.4

≤0.001

0.52

0.60

0.04

0.97

Allelic

368 /552

1.15

0.36 – 3.61 (0.81)

91.9

≤0.001

0.52

0.60

0.14

0.91

CT vs.CC

368 /552

1.50

0.52 – 4.35 (0.45)

85.9

≤0.001

0.52

0.60

-0.10

0.93

  1. * Egger’s test was not calculable