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Fig. 1 | BMC Neurology

Fig. 1

From: Study protocol of the DUtch PARkinson Cohort (DUPARC): a prospective, observational study of de novo Parkinson’s disease patients for the identification and validation of biomarkers for Parkinson’s disease subtypes, progression and pathophysiology

Fig. 1

Baseline recruitment and assessments from Q4 2017 to Q3 2020 of treatment-naïve de novo PD subjects through the collaborative network of PD treating neurologists Parkinson Platform Northern Netherlands (PPNN). 1. Study procedures start at home with 1a. the collection of a saliva sample for genetic screening; 1b. Assessments of gastrointestinal function and stool sample collection; 1c. questionnaire assessments. 2. Participants visit the University Medical Center Groningen (UMCG) on 2 days for 2a. a complete cognitive assessment; 2b. imaging; 2c. ophthalmological assessments; 2d. clinical assessments. * In a subset of participants, intestinal wall permeability will also be assessed using blood samples and a urinary excretion test. ** Hyposmia is also assessed using the Sniffin’ sticks. Source clipart: clipart-library.com

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BMC Neurology

ISSN: 1471-2377

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