Assessments | Endpoint | Baseline | Follow-up 1 year | Follow-up 3 years |
---|---|---|---|---|
Cognition | ||||
Montreal cognitive assessment | Cognitive screening | X | X | X |
Rey auditory verbal learning test | Learning and memory | X | X | |
Location learning test | Learning and memory | X | X | |
Wechsler Adult Intelligence Scale IV: Digit Span | Learning and memory | X | X | |
Wisconsin card sorting test | Executive functioning | X | X | |
Letterfluency | Executive functioning | X | X | |
Hayling sentence completion test | Executive functioning | X | X | |
Stroop color word test | Complex attention | X | X | |
Trail making test | Complex attention | X | X | |
Vienna Test System Reaction time test | Complex attention | X | X | |
Boston naming test | Language | X | X | |
Semantic Fluency | Language | X | X | |
Test of everyday attention: Map search | Perceptual-motor function | X | X | |
Judgment of line orientation | Perceptual-motor function | X | X | |
Facial expression of emotion: Stimuli and tests | Social cognition | X | X | |
Dutch adult reading test | Premorbid intelligence | X | X | |
Vision | ||||
Farnsworth D15, Lanthony D15 | Color vision | X | X | |
Optical Coherence Tomography | Structural retinal imaging | X | X | |
HFA2 SITA Fast | Peripheral vision | X | X | |
Pelli Robson Contrast Sensitivity | Contrast sensitivity | X | X | |
Non-contact tonometry | Intraocular pressure | X | X | |
Visual acuity | Visual acuity | X | X | |
Gastrointestinal function | ||||
16S rRNA gene and metagenomic sequencing | Fecal microbiome composition | X | X | |
Stool diary (7 days) | Stool frequency and consistency | X | X | |
Dietary diary (3 days) | Nutrient intake | X | X | |
Fecal calprotectin | Intestinal wall permeability - inflammation | X | ||
Fecal alpha1-antitrypsin | Intestinal wall permeability - protein leakage | X | ||
Serum zonulina | Intestinal wall permeability - mucosal barrier integrity | X | ||
Urinary sugar excretion testa | Intestinal wall permeability | X | ||
Serum LPSa | Intestinal wall permeability - microbial translocation | X | ||
Other non-motor symptom assessment | ||||
Sniffin’ Sticks | Hyposmia | X | X | |
Non Motor Symptom Questionnaire | Non-motor symptoms screening | X | X | X |
REM Sleep Behavioral Disorder Questionnaire | REM sleep behavioral disorder | X | X | X |
Hospital Anxiety and Depression Scale | Anxiety and depression | X | X | X |
Dutch Multifactor Fatigue Scale | Fatigue | X | X | X |
Apathy Evaluation Scale | Apathy | X | X | X |
Questionnaire for Impulsive-Compulsive Disorder in Parkinson’s Disease Rating Scale | Impulsive-compulsive disorder | X | X | X |
Motor assessment | ||||
MDS-UPDRS III | Motor functioning | X | X | X |
Hoehn & Yahr | Disease severity | X | X | X |
MDS-UPDRS IV | Motor complications dopaminergic medication | X | X | |
Burden of disease | ||||
MDS-UPDRS II | Motor aspects of experiences of daily living | X | X | X |
Utrechtse coping lijst | Coping | X | X | X |
Parkinson’s Disease Quality of Life Questionnaire 39 | Quality of life | X | X | X |
Dysexecutive Questionnaire | Dysexecutive syndrome | X | X | X |
Zarit Caregiver Burden inventory | Caregiver burden | X | X | X |
General information | ||||
Disease History | X | X | X | |
Demographics | X | X | ||
Imaging | ||||
FDOPA PET | Brain dopaminergic imaging | X | X | |
FEOBV PET | Brain cholinergic imaging | X | X | |
MRI brain – Resting State | X | X | ||
MRI brain – Diffusion Tensor Imaging | X | X | ||
MRI brain – Arterial Spin Labeling | X | X | ||
MRI brain – T1 | X | X | ||
MRI brain – T2 | X | X | ||
MRI brain - Susceptibility Weighted Imaging | X | X | ||
Genetics | ||||
GSA-MD | Genome-wide genotyping | X | ||
Blood samplesa | ||||
Plasma EDTA (8 × 2 ml aliquots) | X | X | ||
Serum (4 × 2 ml aliquots) | X | X | ||
Buffy coat (2x) | X | X |