Outcome | Description |
---|---|
Primary outcome | The ratio of mRS ≤ 2 at 90 days after the stroke onset |
Secondary outcome | 1. The ratio of NIHSS decreased ≥4 points at 7 days after the stroke onset |
2. The ratio of parenchymal hemorrhagic transformation in cranial CT within 96 h after the onset | |
3. The ratio of midline shift ≥6 mm in cranial CT within 96 h after the onset | |
4. The mRS shift at 90 days after the onset | |
5. The ratio of Barthel Index of 60–100 points at 90 days after the onset | |
6. The proportion of Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) of ≤3.40 at 6 months and 1 year after the stroke onset | |
7. The serum concentration of MMP-9 at baseline, and at 24, 48, and 72 h after onset | |
Safety outcome | 1. The mortality at 90 days after the onset |
2. The ratio of neurological deterioration (NIHSS increased ≥4 points) within 24 h after the onset | |
3. The incidence of hypoglycemia (random blood glucose < 3.9 mmol/L) | |
4. The incidence of cardiac events in cardiac examination (ECG, echocardiography) | |
5. The incidence of pulmonary infection | |
6. The incidence of adverse event and serious adverse event |