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Table 3 Neurologic outcomes using the GAS scoring system and Barthel scores in all patients with Wilson’s disease during treatment

From: Combined sodium Dimercaptopropanesulfonate and zinc versus D-penicillamine as first-line therapy for neurological Wilson’s disease

 

Baseline

2 weeks

4 weeks

8 weeks

1 year

Group 1

 

N = 93

N = 93

N = 93

N = 93

N = 93

GAS scores

8.74 ± 2.99

8.79 ± 2.90

8.46 ± 3.07

6.79 ± 2.27**

5.89 ± 2.11**

Deterioration (n, %)

 

7/93 (7.52%)

11/93 (11.8%)

10/93 (10.8%)

8/93 (8.6%)

Improvement (n, %)

 

9/93 (9.6%)

37/93 (39.8%)

64/93 (68.8%)

82/93 (88.2%)

Barthel scores

54.52 ± 14.20

55.01 ± 14.71

56.99 ± 15.34

66.51 ± 15.51**

74.68 ± 16.15**

Group 2

 

N = 65

N = 65

N = 65

N = 59

N = 59

GAS scores

8.40 ± 3.49

8.69 ± 3.44

9.20 ± 3.89*

8.17 ± 3.57

7.89 ± 3.76

Deterioration (n, %)

 

13/65 (20%)

22/65 (33.8%)

21/65 (32.3%)

17/65 (26.2%)

Improvement (n, %)

 

8/65 (12.30%)

19/65 (29.2%)

30/65 (46.1%)

37/65 (58.5%)

Barthel scores

58.38 ± 18.65

57.08 ± 17.92

53.23 ± 19.27

61.52 ± 18.67

64.57 ± 21.27

  1. Group 1: treated by sodium 2, 3-dimercapto-1-propane sulfonate in combination of zinc; Group 2: treated by D-penicillamine; Global Assessment Scale, GAS Compared with baseline, *P < 0.05, **P < 0.01