Skip to main content

Table 3 Bivariate associations of maximum ICP, ICP on the affected side of the brain, mean ICP and individual measurements of ICP (left and right side per patient) with categorical explanatory variables

From: Changing the paradigm of intracranial hypertension in brain tumor patients: a study based on non-invasive ICP measurements

Variable

%

ICPmax ES [95% CI]

P-value ICPmax

ICPaff ES [95% CI]

P-value ICPaff

ICPmean ES [95% CI]

P-value

ICPmean

ICPall ES [95% CI]

P-value ICPall

Sex (male vs. Female)

60

−0.04 [−2.48, 3.47]

0.97

0.07 [−2.05, 2.06]

0.97

0.90 [−1.12, 2.72]

0.31

0.44 [−1.32, 2.20]

0.605

Intraaxial

70

−0.91 [−4.57, 2.06]

0.40

− 0.84 [− 2.47, 1.47]

0.31

− 0.10 [− 2.91, 2.53]

0.97

− 0.30 [− 2.19, 1.59]

0.743

Neurological Deficits

90

−5.81 [−9.13, − 1.79]

0.02

− 2.18 [− 4.92, 0.55]

0.32

−5.39 [−8.06, −3.12]

0.01

−5.05 [−7.94, − 2.15]

0.002

Steroids

55

− 0.93 [− 4.18, 1.10]

0.50

− 0.11 [− 2.17, 1.25]

0.74

−0.78 [− 2.52, 1.05]

0.37

−1.25 [− 2.80, 0.30]

0.107

Clinical signs of ICH

30

1.00 [−1.57, 3.74]

0.31

1.05 [−0.11, 2.97]

0.12

0.45 [−1.48, 2.97]

0.60

0.02 [−1.87, 1.91]

0.983

Hemorrhage

10

−1.95 [−7.50, 2.57]

0.32

−0.13 [−3.47, 3.53]

1.00

−0.20 [−3.83, 3.17]

1.00

− 0.33 [− 4.33, 3.66]

0.864

Hydrocephalus

25

0.27 [−3.50, 3.08]

0.80

0.72 [−1.37, 2.72]

0.23

0.11 [−2.32, 2.10]

0.87

−0.28 [− 2.28, 1.72]

0.771

Age (> 60 y vs. ≤ 60 y)

55

−1.73 [− 1.57, 3.68]

0.20

−0.55 [− 1.37, 2.42]

0.36

0.73 [− 1.20, 2.62]

0.33

0.21 [− 1.53, 1.95]

0.799

Cerebrum vs. Cerebellum

85

−1.08 [−4.37, 3.50]

0.31

−1.05 [−3.35, 1.47]

0.24

0.36 [− 1.77, 2.53]

0.76

0.41 [− 1.83, 2.64]

0.707

Solid vs. Necrotic tumor

60

1.88 [−0.81, 4.00]

0.13

0.24 [−1.64, 1.92]

0.68

0.55 [−1.74, 2.45]

0.68

0.33 [−1.45, 2.11]

0.701

Histology

 Glioma

30

NA [NA, NA]

0.63

NA [NA, NA]

0.56

NA [NA, NA]

0.95

0.41 [−1.86, 2.69]

0.707

 Meningioma

30

 Metastasis

40

Tumor location

 left

45

NA [NA, NA]

0.92

NA [NA, NA]

0.87

NA [NA, NA]

0.85

0.27 [−2.04, 2.57]

0.81

 right

30

 bilateral

25

Tumor volume (cm3)

 

0.00 [−0.02, 0.03]

0.84

0.01 [−0.01, 0.02]

0.31

0.00 [−0.02, 0.02]

0.955

−0.00 [− 0.02, 0.01]

0.864

Edema volume (cm3)

0.00 [−0.02, 0.02]

0.84

−0.00 [− 0.01, 0.01]

0.76

0.01 [− 0.01, 0.02]

0.218

0.01 [− 0.01, 0.02]

0.308

Midline shift (mm)

0.09 [−0.13, 0.32]

0.39

0.05 [−0.09, 0.20]

0.43

0.16 [−0.01, 0.32]

0.066

0.10 [−0.07, 0.26]

0.230

Tumor+edema vol. (cm3)

0.00 [−0.01, 0.02]

0.75

0.00 [−0.01, 0.01]

0.66

0.01 [−0.01, 0.02]

0.257

0.00 [−0.01, 0.01]

0.447

Max. tumor diam. (cm)

0.33 [−0.41, 1.07]

0.36

0.31 [−0.09, 0.71]

0.12

0.10 [−0.50, 0.70]

0.720

0.11 [−0.39, 0.61]

0.658

  1. Abbr: CI confidence intervals, ES estimated effect size, ICPall all individual ICP measurements, NA not available