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Table 3 Bivariate associations of maximum ICP, ICP on the affected side of the brain, mean ICP and individual measurements of ICP (left and right side per patient) with categorical explanatory variables

From: Changing the paradigm of intracranial hypertension in brain tumor patients: a study based on non-invasive ICP measurements

Variable % ICPmax ES [95% CI] P-value ICPmax ICPaff ES [95% CI] P-value ICPaff ICPmean ES [95% CI] P-value
ICPmean
ICPall ES [95% CI] P-value ICPall
Sex (male vs. Female) 60 −0.04 [−2.48, 3.47] 0.97 0.07 [−2.05, 2.06] 0.97 0.90 [−1.12, 2.72] 0.31 0.44 [−1.32, 2.20] 0.605
Intraaxial 70 −0.91 [−4.57, 2.06] 0.40 − 0.84 [− 2.47, 1.47] 0.31 − 0.10 [− 2.91, 2.53] 0.97 − 0.30 [− 2.19, 1.59] 0.743
Neurological Deficits 90 −5.81 [−9.13, − 1.79] 0.02 − 2.18 [− 4.92, 0.55] 0.32 −5.39 [−8.06, −3.12] 0.01 −5.05 [−7.94, − 2.15] 0.002
Steroids 55 − 0.93 [− 4.18, 1.10] 0.50 − 0.11 [− 2.17, 1.25] 0.74 −0.78 [− 2.52, 1.05] 0.37 −1.25 [− 2.80, 0.30] 0.107
Clinical signs of ICH 30 1.00 [−1.57, 3.74] 0.31 1.05 [−0.11, 2.97] 0.12 0.45 [−1.48, 2.97] 0.60 0.02 [−1.87, 1.91] 0.983
Hemorrhage 10 −1.95 [−7.50, 2.57] 0.32 −0.13 [−3.47, 3.53] 1.00 −0.20 [−3.83, 3.17] 1.00 − 0.33 [− 4.33, 3.66] 0.864
Hydrocephalus 25 0.27 [−3.50, 3.08] 0.80 0.72 [−1.37, 2.72] 0.23 0.11 [−2.32, 2.10] 0.87 −0.28 [− 2.28, 1.72] 0.771
Age (> 60 y vs. ≤ 60 y) 55 −1.73 [− 1.57, 3.68] 0.20 −0.55 [− 1.37, 2.42] 0.36 0.73 [− 1.20, 2.62] 0.33 0.21 [− 1.53, 1.95] 0.799
Cerebrum vs. Cerebellum 85 −1.08 [−4.37, 3.50] 0.31 −1.05 [−3.35, 1.47] 0.24 0.36 [− 1.77, 2.53] 0.76 0.41 [− 1.83, 2.64] 0.707
Solid vs. Necrotic tumor 60 1.88 [−0.81, 4.00] 0.13 0.24 [−1.64, 1.92] 0.68 0.55 [−1.74, 2.45] 0.68 0.33 [−1.45, 2.11] 0.701
Histology
 Glioma 30 NA [NA, NA] 0.63 NA [NA, NA] 0.56 NA [NA, NA] 0.95 0.41 [−1.86, 2.69] 0.707
 Meningioma 30
 Metastasis 40
Tumor location
 left 45 NA [NA, NA] 0.92 NA [NA, NA] 0.87 NA [NA, NA] 0.85 0.27 [−2.04, 2.57] 0.81
 right 30
 bilateral 25
Tumor volume (cm3)   0.00 [−0.02, 0.03] 0.84 0.01 [−0.01, 0.02] 0.31 0.00 [−0.02, 0.02] 0.955 −0.00 [− 0.02, 0.01] 0.864
Edema volume (cm3) 0.00 [−0.02, 0.02] 0.84 −0.00 [− 0.01, 0.01] 0.76 0.01 [− 0.01, 0.02] 0.218 0.01 [− 0.01, 0.02] 0.308
Midline shift (mm) 0.09 [−0.13, 0.32] 0.39 0.05 [−0.09, 0.20] 0.43 0.16 [−0.01, 0.32] 0.066 0.10 [−0.07, 0.26] 0.230
Tumor+edema vol. (cm3) 0.00 [−0.01, 0.02] 0.75 0.00 [−0.01, 0.01] 0.66 0.01 [−0.01, 0.02] 0.257 0.00 [−0.01, 0.01] 0.447
Max. tumor diam. (cm) 0.33 [−0.41, 1.07] 0.36 0.31 [−0.09, 0.71] 0.12 0.10 [−0.50, 0.70] 0.720 0.11 [−0.39, 0.61] 0.658
  1. Abbr: CI confidence intervals, ES estimated effect size, ICPall all individual ICP measurements, NA not available