Table 2 Summary of MR features per mRNA-based subgroup
From: Radiogenomics correlation between MR imaging features and mRNA-based subtypes in lower-grade glioma
| Â | R1 | R2 | R3 | R4 | |||||
|---|---|---|---|---|---|---|---|---|---|
Negative | Positive | Negative | Positive | Negative | Positive | Negative | Positive | ||
Necrosis/cystic | Negative | 25 (24.04) | 5 (12.2) | 16 (15.24) | 14 (35) | 29 (23.02) | 1 (5.26) | 20 (20) | 10 (22.22) |
Positive | 79 (75.96) | 36 (87.8) | 89 (84.76) | 26 (65) | 97 (76.98) | 18 (94.74) | 80 (80) | 35 (77.78) | |
Multifocality | Negative | 97 (93.27) | 41 (100) | 104 (99.05) | 34 (85) | 119 (94.44) | 19 (100) | 94 (94) | 44 (97.78) |
Positive | 7 (6.73) | 0 (0) | 1 (0.95) | 6 (15) | 7 (5.56) | 0 (0) | 6 (6) | 1 (2.22) | |
Hemorrhage | Negative | 86 (82.69) | 38 (92.68) | 90 (85.71) | 34 (85) | 114 (90.48) | 10 (52.63) | 82 (82) | 42 (93.33) |
| Â | Positive | 18 (17.31) | 3 (7.32) | 15 (14.29) | 6 (15) | 12 (9.52) | 9 (47.37) | 18 (18) | 3 (6.67) |
Degree of enhancement | Negative | 38 (39.18) | 20 (50) | 52 (52.53) | 6 (15.79) | 51 (43.22) | 7 (36.84) | 33 (34.02) | 25 (62.5) |
| Â | Positive | 59 (60.82) | 20 (50) | 47 (47.47) | 32 (84.21) | 67 (56.78) | 12 (63.16) | 64 (65.98) | 15 (37.5) |
Proportion CE Tumor | Negative | 59 (60.82) | 31 (77.5) | 79 (79.8) | 11 (28.95) | 78 (66.1) | 12 (63.16) | 54 (55.67) | 36 (90) |
| Â | Positive | 38 (39.18) | 9 (22.5) | 20 (20.2) | 27 (71.05) | 40 (33.9) | 7 (36.84) | 43 (44.33) | 4 (10) |
Enhancing Margin | Well-defined | 33 (34.02) | 2 (5) | 23 (23.23) | 12 (31.58) | 29 (24.58) | 6 (31.58) | 20 (20.62) | 15 (37.5) |
| Â | Poorly-defined | 64 (65.98) | 38 (95) | 76 (76.77) | 26 (68.42) | 89 (75.42) | 13 (68.42) | 77 (79.38) | 25 (62.5) |
Extranodular Growth | Negative | 73 (75.26) | 38 (95) | 89 (89.9) | 22 (57.89) | 97 (82.2) | 14 (73.68) | 74 (76.29) | 37 (92.5) |
| Â | Positive | 24 (24.74) | 2 (5) | 10 (10.1) | 16 (42.11) | 21 (17.8) | 5 (26.32) | 23 (23.71) | 3 (7.5) |
T1 + C/T2 Mismatch | Negative | 76 (78.35) | 39 (97.5) | 89 (89.9) | 26 (68.42) | 102 (86.44) | 13 (68.42) | 78 (80.41) | 37 (92.5) |
| Â | Positive | 21 (21.65) | 1 (2.5) | 10 (10.1) | 12 (31.58) | 16 (13.56) | 6 (31.58) | 19 (19.59) | 3 (7.5) |
CS | > 30 mm | 47 (46.53) | 24 (58.54) | 52 (50) | 19 (50) | 63 (51.22) | 8 (42.11) | 51 (52.04) | 20 (45.45) |
|  | <=30 mm | 54 (53.47) | 17 (41.46) | 52 (50) | 19 (50) | 60 (48.78) | 11 (57.89) | 47 (47.96) | 24 (54.55) |
Location | Other | 65 (62.5) | 24 (58.54) | 60 (57.14) | 29 (72.5) | 81 (64.29) | 8 (42.11) | 61 (61) | 28 (62.22) |
| Â | Frontal lobe | 39 (37.5) | 17 (41.46) | 45 (42.86) | 11 (27.5) | 45 (35.71) | 11 (57.89) | 39 (39) | 17 (37.78) |
SVZ | Negative | 40 (38.46) | 16 (39.02) | 41 (39.05) | 15 (37.5) | 48 (38.1) | 8 (42.11) | 39 (39) | 17 (37.78) |
| Â | Positive | 64 (61.54) | 25 (60.98) | 64 (60.95) | 25 (62.5) | 78 (61.9) | 11 (57.89) | 61 (61) | 28 (62.22) |
Volume | <60cm3 | 38 (36.54) | 8 (19.51) | 28 (26.67) | 18 (45) | 41 (32.54) | 5 (26.32) | 31 (31) | 15 (33.33) |
|  | > = 60 cm3 | 66 (63.46) | 33 (80.49) | 77 (73.33) | 22 (55) | 85 (67.46) | 14 (73.68) | 69 (69) | 30 (66.67) |
Intratumoral vascular | Negative | 1 (1.03) | 2 (5) | 2 (2.02) | 1 (2.63) | 3 (2.54) | 0 (0) | 3 (3.09) | 0 (0) |
| Â | Positive | 96 (98.97) | 38 (95) | 97 (97.98) | 37 (97.37) | 115 (97.46) | 19 (100) | 94 (96.91) | 40 (100) |
Length | <median | 57 (54.81) | 19 (46.34) | 54 (51.43) | 22 (55) | 66 (52.38) | 10 (52.63) | 51 (51) | 25 (55.56) |
|  | > = median | 47 (45.19) | 22 (53.66) | 51 (48.57) | 18 (45) | 60 (47.62) | 9 (47.37) | 49 (49) | 20 (44.44) |
Width | <median | 58 (55.77) | 16 (39.02) | 50 (47.62) | 24 (60) | 64 (50.79) | 10 (52.63) | 50 (50) | 24 (53.33) |
|  | > = median | 46 (44.23) | 25 (60.98) | 55 (52.38) | 16 (40) | 62 (49.21) | 9 (47.37) | 50 (50) | 21 (46.67) |
Depth | <median | 58 (55.77) | 18 (43.9) | 49 (46.67) | 27 (67.5) | 68 (53.97) | 8 (42.11) | 53 (53) | 23 (51.11) |
|  | > = median | 46 (44.23) | 23 (56.1) | 56 (53.33) | 13 (32.5) | 58 (46.03) | 11 (57.89) | 47 (47) | 22 (48.89) |
Length-Width Ratio | <median | 56 (53.85) | 21 (51.22) | 54 (51.43) | 23 (57.5) | 66 (52.38) | 11 (57.89) | 55 (55) | 22 (48.89) |
|  | > = median | 48 (46.15) | 20 (48.78) | 51 (48.57) | 17 (42.5) | 60 (47.62) | 8 (42.11) | 45 (45) | 23 (51.11) |
Length-Depth Ratio | <median | 53 (50.96) | 22 (53.66) | 54 (51.43) | 21 (52.5) | 64 (50.79) | 11 (57.89) | 54 (54) | 21 (46.67) |
|  | > = median | 51 (49.04) | 19 (46.34) | 51 (48.57) | 19 (47.5) | 62 (49.21) | 8 (42.11) | 46 (46) | 24 (53.33) |
L/CS Ratio | <median | 50 (49.5) | 21 (51.22) | 50 (48.08) | 21 (55.26) | 62 (50.41) | 9 (47.37) | 51 (52.04) | 20 (45.45) |
|  | > = median | 51 (50.5) | 20 (48.78) | 54 (51.92) | 17 (44.74) | 61 (49.59) | 10 (52.63) | 47 (47.96) | 24 (54.55) |
Volume | <median | 56 (53.85) | 18 (43.9) | 50 (47.62) | 24 (60) | 66 (52.38) | 8 (42.11) | 50 (50) | 24 (53.33) |
|  | > = median | 48 (46.15) | 23 (56.1) | 55 (52.38) | 16 (40) | 60 (47.62) | 11 (57.89) | 50 (50) | 21 (46.67) |