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Table 1 Patient characteristics

From: Factors associated with insufficient response to acute treatment of migraine in Japan: analysis of real-world data from the Adelphi Migraine Disease Specific Programme

  Insufficient responders (N = 227) Sufficient responders (N = 311) Total (N = 538)
Age (years, mean ± SD) 43.6 ± 13.4 44.5 ± 14.1 44.1 ± 13.8
Female, n (%) 180 (79.3) 235 (75.6) 415 (77.1)
Smoking status: current or prior smoker, n (%) 45 (20.3) 71 (23.9) 116 (22.4)
Neurologist consultation, n (%)* 117 (51.5) 98 (31.5) 215 (40.0)
Migraine/headache specialista, n (%)* 103 (45.4) 101 (32.5) 204 (37.9)
Employed, n (%) 138 (63.0) 198 (64.5) 336 (63.9)
Number of migraine headache days/month, n (%)
 0–3 103 (59.9) 151 (63.7) 254 (62.1)
 4–7 44 (25.6) 58 (24.5) 102 (24.9)
  ≥ 8 25 (14.5) 28 (11.8) 53 (13.0)
Chronic/episodic migraine, n (%)*
 Chronic migraine 20 (8.8) 11 (3.6) 31 (5.9)
 Episodic migraine 206 (91.2) 291 (96.4) 497 (94.1)
Migraine with aura, n (%) 82 (36.1) 121 (38.9) 203 (37.7)
Family history of migraine: parent, n (%) 45 (20.5) 55 (17.8) 100 (18.9)
Rebound headache or medication-overuse headache, n (%)* 15 (6.6) 9 (2.9) 24 (4.5)
Tension-type headache, n (%) * 63 (27.8) 51 (16.4) 114 (21.2)
Comorbidity (yes), n (%) 103 (45.4) 149 (47.9) 252 (46.8)
 Hypertensionb 23 (22.3) 46 (30.9) 69 (27.4)
 Hyperlipidemiab 20 (19.4) 32 (21.5) 52 (20.6)
 Anxietyb 18 (17.5) 23 (15.4) 41 (16.3)
 Sleep disordersb 15 (14.6) 21 (14.1) 36 (14.3)
 Asthma/COPD/allergic rhinitisb 15 (14.6) 17 (11.4) 32 (12.7)
 Depressionb 13 (12.6) 11 (7.4) 24 (9.5)
 GI problems/dyspepsiab 10 (9.7) 19 (12.8) 29 (11.5)
 Otherb 16 (15.5) 22 (14.8) 38 (15.1)
 Cardiovascular disease,b,c 23 (22.3) 47 (31.5) 70 (27.8)
  1. Physician-reported data
  2. *p < 0.05 between insufficient responders and sufficient responders (variables with significant differences in bold). For categorical measures, chi-squared or Fisher’s exact test was used. For continuous measures, t-test was used
  3. aPatients visited migraine/headache specialists who were either neurologists (n = 164; 30.5% of patients) or internists (n = 40; 7.4% of patients)
  4. bPercentages calculated based on the respective number of patients in each group with any comorbidity. Percentages are calculated as proportion of non-missing data. Comorbidities listed are those occurring in ≥10% of patients experiencing a comorbidity. Chronic migraine was defined as (≥15 headache days per month [15]); episodic migraine was defined as not fulfilling chronic migraine criteria [16]
  5. cCardiovascular disease is a derived variable that includes angina (seen in 1/2 insufficient/sufficient responders, respectively), hypertension (data in table), ischemic heart disease (seen in 0/2 insufficient/sufficient responders, respectively), post myocardial infarction (no occurrences in either group, and congestive heart failure (no occurrences in either group)
  6. COPD chronic obstructive pulmonary disease; GI gastrointestinal; SD standard deviation