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Fig. 3 | BMC Neurology

Fig. 3

From: Molecular abnormalities in autopsied brain tissue from the inferior horn of the lateral ventricles of nonagenarians and Alzheimer disease patients

Fig. 3

Top 5 Upstream Regulators in the inferior horn of the lateral ventricles. PPARGC1A (PPARG Coactivator 1 Alpha), 14–3-3 protein gamma (or Protein kinase C inhibitor protein 1), PSEN1 (Presenilin 1), MAPT (Microtubule associated protein tau gene), and APP (amyloid precursor protein) were the top five upstream regulators identified by IPA. P values were determined based on analyses of the significant overlap between genes/proteins in our dataset and known targets regulated by the Upstream master regulator. All 5 upstream regulators were observed from our 3 combinations of Control vs AD, control vs nonagenarian and nonagenarian vs AD cases

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