Skip to main content

Table 1 (A) Top panel shows list of individual cases, their demographics, pathological score at autopsy and randomization of samples for Tandem Mass Tag isobaric 10-plex multiplexing. (B) Bottom panel shows mean estimates of relevant demographics, post-mortem interval (PMI) time, pathological score at autopsy for patients across the three different populations investigated

From: Molecular abnormalities in autopsied brain tissue from the inferior horn of the lateral ventricles of nonagenarians and Alzheimer disease patients

A
Cases Disease CDR score Sex (M/F) Mean plaque score Braak-staging (I-VI) TMT isobaric label Plex group
1 Healthy Controls 0 F 0 0 -128C Plex A
2 Healthy Controls 0 F 0 I -128N Plex A
3 Healthy Controls 0 M 0 I -129C Plex A
4 Healthy Controls 0.5 M 0 II -128C Plex B
5 Healthy Controls 0 M 0.26 II -128N Plex B
6 Healthy Controls 0 M 0 0 -131 [ref] Plex A, B, C
7 Healthy Controls 0.5 F 0 II -129C Plex B
8 Healthy Controls 0.5 M 0 I -126 Plex C
9 Healthy Controls 0 F 0 0 -127C Plex C
10 Nonagenerians 0 F 5.356 V -127N Plex B
11 Nonagenerians 0 F 1.944 IV -126 Plex A
12 Nonagenerians 0.5 F 3.754 IV -127C Plex A
13 Nonagenerians 0 M 1.95 IV -127N Plex A
14 Nonagenerians 0.5 F 7.49 V -126 Plex B
15 Nonagenerians 0.5 F 7.49 VI -127C Plex A
16 Alzheimer's Disease 4 M 29.76 VI -129N Plex A
17 Alzheimer's Disease 3 M 18.88 VI -130C Plex A
18 Alzheimer's Disease 2 F 19.12 VI -130N Plex A
19 Alzheimer's Disease 2 F 20.24 VI -129C Plex C
20 Alzheimer's Disease 1 M 6.72 VI -128C Plex C
21 Alzheimer's Disease 2 M 12.58 VI -130C Plex C
22 Alzheimer's Disease 3 F 9.17 VI -127N Plex C
23 Alzheimer's Disease 1 F 24.15 VI -129N Plex B
24 Alzheimer's Disease 3 F 20.48 VI -130C Plex B
25 Alzheimer's Disease 2 M 22.47 VI -130N Plex B
26 Alzheimer's Disease 3 F 31.96 VI -128N Plex C
B
Disease group Mean PMI mins (±SEM) Mean CDR score (±SEM) Mean age Yrs (±SEM) Male (%) Female (%) Mean plaque score (±SEM) Braak-staging (±SEM) Sample size (N)
Healthy Control 601.6±94.6 0.17±0.08 77.2±0.6 55.6% (5/9) 44.4% (4/9) 0.03±0.03 1±0.3 9
Nonagenerians 448±110.7 0.25±0.11 93.2±1.1 16.7% (1/6) 83.3% (5/6) 4.66±1.03 4.67±0.3 6
Alzheimer's Disease 441.8±76.2 2.36±0.28 77.0±0.5 45.5% (5/11) 54.5% (5/11) 19.59±2.36 6±0.0 11