Variable | Effect size | ||
---|---|---|---|
SMD (95% CI) | p value | Heterogeneity (p value) | |
Species | |||
 Mice | 1.37 (−0.53 to 3.27) | 0.157 | 79.2% (0.008) |
 Rat | 2.81 (1.82 to 3.80) | < 0.0001 | 87.4% (< 0.0001) |
Duration of occlusion | |||
 ≤ 60 min | 2.85 (0.92 to 4.77) | < 0.0001 | 86.9% (< 0.0001) |
 > 60 min | 2.48 (1.45 to 3.51) | 0.004 | 87.9% (< 0.0001) |
Stroke model | |||
 MCAO | 2.35 (1.50 to 3.23) | < 0.0001 | 84.5% (< 0.0001) |
 Carotid clamp | 3.72 (−0.66 to 8.09) | 0.096 | 93.3% (< 0.0001) |
Type of administration | |||
 Intracranial | 2.78 (0.40 to 5.16) | 0.022 | 89.0% (< 0.0001) |
 Intravenous | 2.84 (1.86 to 3.80) | < 0.0001 | 78.9% (< 0.0001) |
 Intra-artery | 0.45 (−0.03 to 0.92) | 0.067 | 0.00% (> 0.999) |
Type of graft | |||
 Autograft | 4.28 (2.62 to 5.94) | < 0.0001 | 36.5% (0.209) |
 Allograft | 2.01 (1.00 to 3.02) | < 0.0001 | 74.5% (0.003) |
 Xenograft | 2.44 (1.13 to 3.74) | < 0.0001 | 88.7% (< 0.0001) |
Number of transplanted cell | |||
 1 × 105 to 5 × 105 | 0.38 (−0.01 to 0.76) | 0.057 | 0.0% (0.620) |
 1 × 106 | 4.64 (3.75 to 5.90) | < 0.0001 | 36.9% (0.160) |
 2 × 106 | 2.35 (1.24 to 3.46) | < 0.0001 | 77.5% (0.004) |
 5 × 106 to 1 × 107 | 1.15 (0.46 to 1.84) | 0.001 | 0.0% (0.603) |
Interval time from stroke to treatment | |||
 0 to 3 h | 2.93 (1.86 to 3.99) | < 0.0001 | 79.8% (< 0.0001) |
 24 h | NA | NA | NA |
 More than 7 days | 2.44 (0.43 to 4.45) | 0.017 | 90.1% (< 0.0001) |
Follow up duration | |||
  < 28 days | 3.37 (2.0 to 4.68) | < 0.0001 | 80.8% (< 0.0001) |
  ≥ 28 days | 1.76 (0.80 to 2.71) | < 0.0001 | 84.1% (< 0.0001) |