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Table 4 Subgroup analysis of ADSCs transplantation on motor function recovery after stroke

From: Efficacy of adipose derived stem cells on functional and neurological improvement following ischemic stroke: a systematic review and meta-analysis

Variable

Effect size

SMD (95% CI)

p value

Heterogeneity (p value)

Species

 Mice

1.37 (−0.53 to 3.27)

0.157

79.2% (0.008)

 Rat

2.81 (1.82 to 3.80)

< 0.0001

87.4% (< 0.0001)

Duration of occlusion

 ≤ 60 min

2.85 (0.92 to 4.77)

< 0.0001

86.9% (< 0.0001)

 > 60 min

2.48 (1.45 to 3.51)

0.004

87.9% (< 0.0001)

Stroke model

 MCAO

2.35 (1.50 to 3.23)

< 0.0001

84.5% (< 0.0001)

 Carotid clamp

3.72 (−0.66 to 8.09)

0.096

93.3% (< 0.0001)

Type of administration

 Intracranial

2.78 (0.40 to 5.16)

0.022

89.0% (< 0.0001)

 Intravenous

2.84 (1.86 to 3.80)

< 0.0001

78.9% (< 0.0001)

 Intra-artery

0.45 (−0.03 to 0.92)

0.067

0.00% (> 0.999)

Type of graft

 Autograft

4.28 (2.62 to 5.94)

< 0.0001

36.5% (0.209)

 Allograft

2.01 (1.00 to 3.02)

< 0.0001

74.5% (0.003)

 Xenograft

2.44 (1.13 to 3.74)

< 0.0001

88.7% (< 0.0001)

Number of transplanted cell

 1 × 105 to 5 × 105

0.38 (−0.01 to 0.76)

0.057

0.0% (0.620)

 1 × 106

4.64 (3.75 to 5.90)

< 0.0001

36.9% (0.160)

 2 × 106

2.35 (1.24 to 3.46)

< 0.0001

77.5% (0.004)

 5 × 106 to 1 × 107

1.15 (0.46 to 1.84)

0.001

0.0% (0.603)

Interval time from stroke to treatment

 0 to 3 h

2.93 (1.86 to 3.99)

< 0.0001

79.8% (< 0.0001)

 24 h

NA

NA

NA

 More than 7 days

2.44 (0.43 to 4.45)

0.017

90.1% (< 0.0001)

Follow up duration

  < 28 days

3.37 (2.0 to 4.68)

< 0.0001

80.8% (< 0.0001)

  ≥ 28 days

1.76 (0.80 to 2.71)

< 0.0001

84.1% (< 0.0001)

  1. CI Confidence interval, MCAO Middle cerebral artery occlusion, NA Not applicable due to limited number of studies in the subgroup, SMD Standardized mean difference