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Table 1 Baseline Characteristics of Patients in the Cerebrolysin and Saline Groups

From: Randomized, placebo-controlled, double-blind, pilot trial to investigate safety and efficacy of Cerebrolysin in patients with aneurysmal subarachnoid hemorrhage

 

Cerebrolysin

n = 25

Saline

n = 25

P-value

Patient Factors

 Age, mean + SD (range), years

52 + 9 (31–65)

54 + 11 (37–70)

0.72

  > 65 years

2

4

0.67

 Female

16

18

0.76

 Smoker

12

9

0.39

 Pre-existing hypertension

11

5

0.07

 Baseline MAP, mean + SD, mmHg

127 + 28

122 + 22

0.45

 Median CCI

1

1

1.00

Disease Factors

 Modified WFNS

  

0.79

  I

11

14

 

  II

4

1

 

  III

1

3

 

  IV

8

6

 

  V

1

1

 

 APACHE II score, mean + SD

11 + 5

9 + 5

0.14

 Modified Fisher CT Grade

  

0.07

  I

3

7

 

  II

3

5

 

  III

12

6

 

  IV

7

7

 

 Hijdra score, mean + SD

17 + 6

16 + 7

0.64

 Hijdra score > 22

6

8

0.53

 Hydrocephalus

11

11

1.00

 Intraventricular hemorrhage

10

10

1.00

 Intracerebral hemorrhage

6

6

1.00

 Rebleeding

0

1

1.00

 Aneurysm location

  

0.53

  ICA

10

11

 

  ACA/ AComA

5

9

 

  MCA

7

3

 

  PC

3

2

 

Treatment Factors

 Aneurysm treatment

  Endovascular therapy

16

19

0.11

  Clipping

9

6

0.36

  1. N.B. MAP mean arterial pressure, CCI Charlson comorbidity index, WFNS World Federation of Neurosurgical Societies, APACHE Acute Physiology and Chronic Health Evaluation, IQR interquartile range, CT computed tomography, ICA internal carotid artery, ACA anterior cerebral artery, AComA anterior communicating artery, MCA middle cerebral artery, PC posterior circulation